Zhang Z, Zhang W, Xu Y, Liu D, et al.
Asian journal of surgery. Date of publication 2022 Jan 1;volume 45(1):68-78.
1. Asian J Surg. 2022 Jan;45(1):68-78. doi: 10.1016/j.asjsur.2021.07.047. Epub
2021 Aug 8.
Efficacy of hyperbaric oxygen therapy for diabetic foot ulcers: An updated
systematic review and meta-analysis.
Zhang Z(1), Zhang W(2), Xu Y(3), Liu D(4).
Author information:
(1)Department of Burns, First Affiliated Hospital of Nanchang University,
Nanchang, Jiangxi 330006, China; The First Clinical Medical School, Nanchang
University, Nanchang, Jiangxi, 330006, China. Electronic address:
1711371646@qq.com.
(2)Department of Burns, First Affiliated Hospital of Nanchang University,
Nanchang, Jiangxi 330006, China; The First Clinical Medical School, Nanchang
University, Nanchang, Jiangxi, 330006, China. Electronic address:
zwj050709@163.com.
(3)Department of Burns, First Affiliated Hospital of Nanchang University,
Nanchang, Jiangxi 330006, China; The First Clinical Medical School, Nanchang
University, Nanchang, Jiangxi, 330006, China. Electronic address:
1170952219@qq.com.
(4)Department of Burns, First Affiliated Hospital of Nanchang University,
Nanchang, Jiangxi 330006, China. Electronic address: dewuliu@126.com.
The present systematic review and meta-analysis was performed to evaluate the
efficacy of hyperbaric oxygen therapy (HBOT) in the treatment of diabetic foot
ulcers (DFUs). Relevant articles were retrieved from PubMed, the Cochrane
Library, EMBASE and other databases through November 2020. A total of 20
randomized clinical trials and 1263 trials were included in the meta-analysis.
For each trial, the average difference, odds ratio and 95% confidence interval
were calculated to evaluate the efficacy. Hyperbaric oxygen therapy increased
the healing rate of diabetic foot ulcers (relative risk, 1.901; 95%
CI = 1.484-2.435, p < 0.0001), shortened the healing time (MD = -19.360; 95%
CI = -28.753~-9.966, p < 0.001), and reduced the incidence of major amputation
(relative risk, 0.518, 95% CI = 0.323-0.830, P < 0.01). In summary, our
meta-analysis confirmed that hyperbaric oxygen therapy offers great benefits in
the treatment of DFU and the reduction of amputation. In addition, larger and
well-designed randomized controlled trials need to be planned and conducted to
verify this conclusion.
Copyright © 2021. Published by Elsevier Taiwan LLC.
DOI: 10.1016/j.asjsur.2021.07.047
PMID: 34376365 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of competing interest All authors
have claimed no conflict of interest.
