Sharma R, Sharma SK, Mudgal SK, Jelly P, Thakur K, et al.
Scientific reports. Date of publication 2021 Jan 26;volume 11(1):2189.
1. Sci Rep. 2021 Jan 26;11(1):2189. doi: 10.1038/s41598-021-81886-1.
Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic
review and meta-analysis of controlled clinical trials.
Sharma R(1), Sharma SK(1), Mudgal SK(2), Jelly P(3), Thakur K(1).
Author information:
(1)College of Nursing, All India Institute of Medical Sciences, Rishikesh,
Uttarakhand, India.
(2)Akal College of Nursing, Eternal University, Baru Sahib, Himachal Pradesh,
India.
(3)College of Nursing, All India Institute of Medical Sciences, Rishikesh,
Uttarakhand, India. prasunajelly@gmail.com.
Studies have suggested that hyperbaric oxygen therapy (HBOT) is effective in the
healing of diabetic foot ulcer (DFU); however, there is a lack of consensus.
Therefore, to assess the efficacy of HBOT on diabetic foot ulcer among diabetic
patients, controlled clinical trials were searched through PubMed, EMBASE,
Clinical key, Ovid Discovery, ERMED, Clinical Trials.gov databases for
randomized controlled trials (RCTs) and other sources until 15 September 2020.
Studies that evaluated the effect of HBOT on diabetic foot ulcer, complete
healing, amputation, adverse events, ulcer reduction area, and mortality rate
were included. Of 1984 study records screened, 14 studies (768 participants)
including twelve RCTs, and two CCTs were included as per inclusion criteria. The
results with pooled analysis have shown that HBOT was significantly effective in
complete healing of diabetic foot ulcer (OR = 0.29; 95% CI 0.14-0.61; I2 = 62%)
and reduction of major amputation (RR = 0.60; 95% CI 0.39-0.92; I2 = 24%).
Although, it was not effective for minor amputations (RR = 0.82; 95% CI
0.34-1.97; I2 = 79%); however, less adverse events were reported in standard
treatment group (RR = 1.68; 95% CI 1.07-2.65; I2 = 0%). Nevertheless, reduction
in mean percentage of ulcer area and mortality rate did not differ in HBOT and
control groups. This review provides an evidence that hyperbaric oxygen therapy
is effective as an adjunct treatment measure for the diabetes foot ulcers. These
findings could be generalized cautiously by considering methodological flaws
within all studies.
DOI: 10.1038/s41598-021-81886-1
PMCID: PMC7838311
PMID: 33500533 [Indexed for MEDLINE]
Conflict of interest statement: The authors declare no competing interests.
