Cho J, Hwang H, Song SY, Suh HP, Hong JP, et al.
International wound journal. Date of publication 2022 Sep 27;volume ():.
1. Int Wound J. 2022 Sep 27. doi: 10.1111/iwj.13958. Online ahead of print.
Evaluation of wound healing effects of micronized acellular dermal matrix in
combination with negative pressure wound therapy: In vivo study.
Cho J(1), Hwang H(2), Song SY(1), Suh HP(1), Hong JP(1).
Author information:
(1)Department of Plastic and Reconstructive Surgery, Asan Medical Center,
University of Ulsan College of Medicine, Seoul, South Korea.
(2)Division of Pediatric Cardiology, Department of Pediatrics, Emory University
School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Acellular dermal matrix (ADM) grafts can provide coverage for full-thickness
skin defects and substitute for dermal defects. We tested the effectiveness of
micronized ADM (mADM) as a dressing material, combined with negative pressure
wound therapy (NPWT), for managing superficial wounds. We compared the wound
healing effect of mADM in combination with NPWT with those of gelatin and mADM
applied with a foam dressing. These therapeutic materials were applied to 36 cm2
excisional wounds in a porcine full-thickness skin defect model. Wound healing
kinetics and new tissue formation were assessed 10 days after the initial
treatment by measuring the wound area. Collagen deposition and
neovascularization were histologically evaluated. Compared with the other two
groups, mADM plus NPWT combination group had a significantly larger wound area
at the baseline (P = .0040), but the smallest on the 7th day (P = .0093). In
addition, collagen formation and neovascularization were more histologically
promoted than in the other two groups. mADM showed better results than the
gelatin group but less collagen and revascularization than the combination
group, and there was no significant difference in wound area. Our results show
that the combination of mADM and NPWT has a synergistic wound healing effect.
© 2022 The Authors. International Wound Journal published by
Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd.
DOI: 10.1111/iwj.13958
PMID: 36165089
