Zhang L, Weng T, Wu P, Li Q, Han C, Wang X, et al.
BioMed research international. Date of publication 2020 Dec 4;volume 2020():8824737.
1. Biomed Res Int. 2020 Dec 4;2020:8824737. doi: 10.1155/2020/8824737.
eCollection 2020.
The Combined Use of Negative-Pressure Wound Therapy and Dermal Substitutes for
Tissue Repair and Regeneration.
Zhang L(1), Weng T(1)(2), Wu P(1), Li Q(1), Han C(1), Wang X(1).
Author information:
(1)Department of Burns & Wound Care Center, The Second Affiliated Hospital,
Zhejiang University College of Medicine, Hangzhou 310009, China.
(2)College of Medicine, Zhejiang University, Hangzhou 310000, China.
In clinical practice, skin defects occur frequently due to various kinds of
acute and chronic diseases. The standard treatment for these wounds is
autografting, which usually results in complications such as scar formation and
new wounds at donor sites. The advent of dermal substitutes has provided a novel
method for wound repair, and rapid angiogenesis of the dermal substitutes is
crucial for the graft to take. At present, many strategies have been developed
to improve the process of vascularisation, some of which have shown promising
potentials, but they could be very far from clinical applications. Most
recently, negative-pressure wound therapy (NPWT) has been used extensively in
clinical practice for wound care and management. It has been reported that NPWT
reduces the time required for vascular ingrowth into the dermal substitute and
improves graft take, indicating great potentials for wound repair. This article
presents a comprehensive overview of the combined use of NPWT and dermal
substitutes for tissue repair and regeneration. Relative concerns and prospects
are also discussed.
Copyright © 2020 Liping Zhang et al.
DOI: 10.1155/2020/8824737
PMCID: PMC7732395
PMID: 33344649 [Indexed for MEDLINE]
Conflict of interest statement: None of the authors have any potential conflicts
of interest to disclose.
