Sun Y, Zhao J, Zhang L, Li Z, Lei S, et al.
Stem cell research & therapy. Date of publication 2022 Aug 13;volume 13(1):416.
1. Stem Cell Res Ther. 2022 Aug 13;13(1):416. doi: 10.1186/s13287-022-03110-9.
Effectiveness and safety of stem cell therapy for diabetic foot: a meta-analysis
update.
Sun Y(1), Zhao J(2), Zhang L(1), Li Z(3), Lei S(4).
Author information:
(1)Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South
University, 87 Xiangya Road, Changsha, 410008, Hunan Province, China.
(2)School of Health Policy and Management, Chinese Academy of Medical Sciences &
Peking Union Medical College, Beijing, 100730, China.
(3)Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South
University, 87 Xiangya Road, Changsha, 410008, Hunan Province, China.
lzxuan11733@163.com.
(4)Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South
University, 87 Xiangya Road, Changsha, 410008, Hunan Province, China.
leishaorong@csu.edu.cn.
BACKGROUND: Diabetic foot (DF) is one of the most common and serious
complications of diabetes mellitus (DM), which brings great psychological and
economic pressure to patients. This study aimed to evaluate the efficacy of stem
cells in the treatment of diabetic foot.
METHODS: All relevant studies in Cochrane, Embase, PubMed, Web of Science, China
National Knowledge Infrastructure, and WanFang databases were systematically
searched for meta-analysis. The outcomes consisted of ulcer or wound healing
rate, amputation rate, new vessels, ankle-brachial index (ABI), transcutaneous
oxygen pressure (TcPO2), pain-free walking distance, and rest pain score.
Dichotomous outcomes were described as risk ratios (RR) with 95% confidence
intervals (CIs), while continuous data were presented as standardized mean
differences (SMDs) with 95% CIs. Statistical analysis was performed with RevMan
5.3 software.
RESULTS: A total of 14 studies with 683 participants were included in the
meta-analysis. Meta-analysis showed that stem cell therapy was more effective
than conventional therapy in terms of ulcer or wound healing rate [OR = 8.20
(5.33, 12.62)], improvement in lower extremity ischemia(new vessels) [OR = 16.48
(2.88, 94.18)], ABI [MD = 0.13 (0.04, 0.08)], TcO2[MD = 4.23 (1.82, 6.65)],
pain-free walking distance [MD = 220.79 (82.10, 359.48)], and rest pain score
[MD = - 1.94 (- 2.50, - 1.39)], while the amputation rate was significantly
decreased [OR = 0.19 (0.10, 0.36)].
CONCLUSIONS: The meta-analysis of the current studies has shown that stem cells
are significantly more effective than traditional methods in the treatment of
diabetic foot and can improve the quality of life of patients after treatment.
Future studies should conduct large-scale, randomized, double-blind,
placebo-controlled, multicenter trials with high-quality long-term follow-up to
demonstrate the most effective cell types and therapeutic parameters for the
treatment of diabetic foot.
© 2022. The Author(s).
DOI: 10.1186/s13287-022-03110-9
PMCID: PMC9375292
PMID: 35964145 [Indexed for MEDLINE]
