Langan SM, Groves RW, Card TR, Gulliford MC, et al.
The Journal of investigative dermatology. Date of publication 2012 Sep 1;volume 132(9):2166-70.
1. J Invest Dermatol. 2012 Sep;132(9):2166-70. doi: 10.1038/jid.2012.130. Epub 2012
Apr 26.
Incidence, mortality, and disease associations of pyoderma gangrenosum in the
United Kingdom: a retrospective cohort study.
Langan SM(1), Groves RW, Card TR, Gulliford MC.
Author information:
(1)Department of Epidemiology and Population Health, London School of Hygiene and
Tropical Medicine, London, UK. sinead.langan@lshtm.ac.uk
Pyoderma gangrenosum (PG) is an important disease with significant complications.
The objectives of this study were to determine incidence and mortality of PG and
strength of reported associations. A retrospective cohort study was completed
using computerized medical records from the General Practice Research Database, a
large representative UK database. Patients with PG and three groups of age-,
sex-, and practice-matched controls--general population, rheumatoid arthritis
(RA), and inflammatory bowel disease (IBD) controls--were included in the study.
Incidence and mortality were determined and validation undertaken to inform
diagnostic accuracy. In all there were 313 people with the median age of 59
(interquartile range 41-72) years, and of them 185 (59%) were female. The
adjusted incidence rate standardized to European standard population was 0.63
(95% confidence interval (CI) 0.57-0.71) per 100,000 person-years. The risk of
death was three times higher than that for general controls (adjusted hazard
ratio=3.03, 95% CI 1.84-4.73, P<0.001), 72% higher than that for IBD controls
(adjusted hazard ratio=1.72, 95% CI 1.17-2.59, P=0.013), with a borderline
increase compared with RA controls (adjusted hazard ratio=1.55, 95% CI 1.01-2.37,
P=0.045). Disease associations were present in 110 (33%) participants: IBD, n=67
(20.2%); RA, n=39 (11.8%); and hematological disorders, n=13 (3.9%). To our
knowledge, there are no previous population-based studies of the epidemiology of
PG, an important disease with significantly increased mortality.
DOI: 10.1038/jid.2012.130
PMID: 22534879 [Indexed for MEDLINE]
