Abdel-Sayed P, Tornay D, Hirt-Burri N, de Buys Roessingh A, Raffoul W, Applegate LA, et al.
Burns : journal of the International Society for Burn Injuries. Date of publication 2020 Aug 1;volume 46(5):1150-1156.
1. Burns. 2020 Aug;46(5):1150-1156. doi: 10.1016/j.burns.2019.12.008. Epub 2020 Jan
3.
Implications of chlorhexidine use in burn units for wound healing.
Abdel-Sayed P(1), Tornay D(2), Hirt-Burri N(1), de Buys Roessingh A(3), Raffoul
W(4), Applegate LA(5).
Author information:
(1)Regenerative Therapy Unit, Lausanne University Hospital, Switzerland; Service
of Plastic, Reconstructive & Hand Surgery, Lausanne University Hospital,
Switzerland.
(2)Regenerative Therapy Unit, Lausanne University Hospital, Switzerland.
(3)Service of Pediatric Surgery, Lausanne University Hospital, Switzerland.
(4)Service of Plastic, Reconstructive & Hand Surgery, Lausanne University
Hospital, Switzerland.
(5)Regenerative Therapy Unit, Lausanne University Hospital, Switzerland; Service
of Plastic, Reconstructive & Hand Surgery, Lausanne University Hospital,
Switzerland. Electronic address: Lee.Laurent-Applegate@chuv.ch.
Comment in
Burns. 2020 Jun;46(4):981-982.
Burns. 2020 Jun;46(4):980-981.
Chlorhexidine is known to be a potent antiseptic with evidence of a beneficial
role in burn care. Nevertheless, several in vitro studies have reported
cytotoxicity on cultured cells, while in vivo and clinical data seem to show more
controversial results. In the frame of this work, we aimed to evaluate the use of
chlorhexidine in burn units worldwide be sending a survey to professionals of the
field. We associated survey results to those perspectives reported in the
literature to update recommendations for the use of chlorhexidine in specific
protocols for burn management. The survey results showed that there is no clear
consensus on the use of chlorhexidine regarding the concentrations, the type of
excipient and the cleansing after application. Literature searches showed
evidence that the skin of premature infants appears to be more sensitive to
chlorhexidine that adult skin, with more reported cases of adverse effects. It
was also determined that aqueous formulations of chlorhexidine do not appear to
be necessarily less efficient than with alcohol as an excipient, and that lower
concentrations are as efficient as higher concentrations. In view of this study,
we have adjusted our protocols for the use of aqueous formulations at low
concentrations and investigated further the role of washing after application in
order to standardize the indication of chlorhexidine and minimize the probability
of adverse effects.
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.burns.2019.12.008
PMID: 31911075 [Indexed for MEDLINE]
