Janowska A, Papa G, Romanelli M, Davini G, Oranges T, Stocco C, Arnez ZM, Dini V, et al.
Journal of investigative surgery : the official journal of the Academy of Surgical Research. Date of publication 2022 Jan 1;volume 35(1):49-52.
1. J Invest Surg. 2022 Jan;35(1):49-52. doi: 10.1080/08941939.2020.1821134. Epub
2020 Sep 24.
5% Lidocaine Hydrochloride Cream for Wound Pain Relief: A Multicentre
Observational Study.
Janowska A(1), Papa G(2), Romanelli M(1), Davini G(1), Oranges T(1)(3), Stocco
C(2), Arnez ZM(2), Dini V(1).
Author information:
(1)Department of Dermatology, University of Pisa, Pisa, Italy.
(2)Department of, Medical, Surgical and Health Sciences, Plastic and
Reconstructive Surgery Unit, University of Trieste, Trieste, Italy.
(3)Department of Health Sciences, Anna Meyer Children University Hospital,
University of Florence, Florence, Italy.
BACKGROUND: Lidocaine hydrochloride is frequently used for management of painful
wounds. This prospective, multicentre study examined the effects of 5% lidocaine
cream on wound pain relief.
MATERIAL AND METHODS: The study included 78 patients with painful wounds treated
with 5% Lidocaine cream for two weeks in two Italian Hospitals. Patients'
perception of pain was recorded by, using the 5-point Visual Rate Scale and the
11-point Numerical Pain Rating Scale. All medications and adverse events were
evaluated in a daily diary. The primary outcome of the study was establishing the
wound pain relief based on the results of 5-VRS and pain intensity based on the
11-NPRS testing from baseline to the end of treatment. Clinical aspects and
adverse events were also collected.
RESULTS: Seventy-eight patients had a median age of 67.5 years (range
18-96 years). 62.8% were women. The wounds included traumatic wounds (n = 39),
venous ulcers (n = 25), post-surgical wounds (n = 6) pyoderma gangrenosum
(n = 6), vasculitis (n = 1) and pressure ulcer (n = 1). The intensity of pain
significantly decreased from the baseline level established at the beginning of
treatment (mean score 6.7 - 1.90) - to the level at end of treatment
(3.0 - 2.23-; p < 0.0001). 9 patients prematurely stopped the treatment for
healing (n = 4), wound improvement (n = 2) and adverse events related to the
treatment. (n = 3). 13 patients presented a total of 25 adverse events, 4 of them
were related to the treatment.
CONCLUSION: The treatment of painful wounds with 5% Lidocaine Cream for 14 days
resulted in reduced pain intensity, and showed high safety and tolerability.
DOI: 10.1080/08941939.2020.1821134
PMID: 32969736 [Indexed for MEDLINE]
