Nielson CB, Duethman NC, Howard JM, Moncure M, Wood JG, et al.
Journal of burn care & research : official publication of the American Burn Association. Date of publication 2017 Jan 1;volume 38(1):e469-e481.
1. J Burn Care Res. 2017 Jan/Feb;38(1):e469-e481. doi: 10.1097/BCR.0000000000000355.
Burns: Pathophysiology of Systemic Complications and Current Management.
Nielson CB(1), Duethman NC, Howard JM, Moncure M, Wood JG.
Author information:
(1)From the *Department of Surgery, and †Department of Molecular & Integrative
Physiology, University of Kansas Medical Center.
As a result of many years of research, the intricate cellular mechanisms of burn
injury are slowly becoming clear. Yet, knowledge of these cellular mechanisms and
a multitude of resulting studies have often failed to translate into improved
clinical treatment for burn injuries. Perhaps the most valuable information to
date is the years of clinical experience and observations in the management and
treatment of patients, which has contributed to a gradual improvement in reported
outcomes of mortality. This review provides a discussion of the cellular
mechanisms and pathways involved in burn injury, resultant systemic effects on
organ systems, current management and treatment, and potential therapies that we
may see implemented in the future.
DOI: 10.1097/BCR.0000000000000355
PMCID: PMC5214064
PMID: 27183443 [Indexed for MEDLINE]
