Paul DW, Ghassemi P, Ramella-Roman JC, Prindeze NJ, Moffatt LT, Alkhalil A, Shupp JW, et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the Eur.... Date of publication 2015 Mar 1;volume 23(2):149-62.
1. Wound Repair Regen. 2015 Mar-Apr;23(2):149-62. doi: 10.1111/wrr.12262.
Noninvasive imaging technologies for cutaneous wound assessment: A review.
Paul DW(1), Ghassemi P(2), Ramella-Roman JC(3), Prindeze NJ(1), Moffatt LT(1),
Alkhalil A(1), Shupp JW(1)(4).
Author information:
(1)The Firefighters' Burn and Surgical Research Laboratory, MedStar Health
Research Institute, Washington, DC.
(2)Department of Electrical Engineering and Computer Science, The Catholic
University of America, Washington, DC.
(3)Department of Biomedical Engineering and Herbert Wertheim College of Medicine,
Florida International University, Miami, Florida.
(4)Department of Surgery, The Burn Center, MedStar Washington Hospital Center,
Washington, DC.
The ability to phenotype wounds for the purposes of assessing severity, healing
potential and treatment is an important function of evidence-based medicine. A
variety of optical technologies are currently in development for noninvasive
wound assessment. To varying extents, these optical technologies have the
potential to supplement traditional clinical wound evaluation and research, by
providing detailed information regarding skin components imperceptible to visual
inspection. These assessments are achieved through quantitative optical analysis
of tissue characteristics including blood flow, collagen remodeling, hemoglobin
content, inflammation, temperature, vascular structure, and water content.
Technologies that have, to this date, been applied to wound assessment include:
near infrared imaging, thermal imaging, optical coherence tomography, orthogonal
polarization spectral imaging, fluorescence imaging, laser Doppler imaging,
microscopy, spatial frequency domain imaging, photoacoustic detection, and
spectral/hyperspectral imaging. We present a review of the technologies in use or
development for these purposes with three aims: (1) providing basic explanations
of imaging technology concepts, (2) reviewing the wound imaging literature, and
(3) providing insight into areas for further application and exploration.
Noninvasive imaging is a promising advancement in wound assessment and all
technologies require further validation.
© 2015 by the Wound Healing Society.
DOI: 10.1111/wrr.12262
PMID: 25832563 [Indexed for MEDLINE]
