Yu X, Jiang W, Shi Y, Ye H, Lin J, et al.
Journal of cellular and molecular medicine. Date of publication 2019 Nov 1;volume 23(11):7143-7150.
1. J Cell Mol Med. 2019 Nov;23(11):7143-7150. doi: 10.1111/jcmm.14624. Epub 2019 Sep
2.
Applications of sequencing technology in clinical microbial infection.
Yu X(1), Jiang W(1), Shi Y(2), Ye H(1), Lin J(2)(3)(4).
Author information:
(1)Department of Infectious Diseases, Mengchao Hepatobiliary Hospital of Fujian
Medical University, Fuzhou, China.
(2)Institute of Apply Genomics, Fuzhou University, Fuzhou, China.
(3)School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
(4)Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fuzhou,
China.
Infectious diseases are a type of disease caused by pathogenic microorganisms.
Although the discovery of antibiotics changed the treatment of infectious
diseases and reduced the mortality of bacterial infections, resistant bacterial
strains have emerged. Anti-infective therapy based on aetiological evidence is
the gold standard for clinical treatment, but the time lag and low positive
culture rate of traditional methods of pathogen diagnosis leads to relative
difficulty in obtaining the evidence of pathogens. Compared with traditional
methods of pathogenic diagnosis, next-generation and third-generation sequencing
technologies have many advantages in the detection of pathogenic microorganisms.
In this review, we mainly introduce recent progress in research on pathogenic
diagnostic technology and the applications of sequencing technology in the
diagnosis of pathogenic microorganisms. This review provides new insights into
the application of sequencing technology in the clinical diagnosis of
microorganisms.
© 2019 The Authors. Journal of Cellular and Molecular Medicine published by John
Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
DOI: 10.1111/jcmm.14624
PMCID: PMC6815769
PMID: 31475453 [Indexed for MEDLINE]
