Kesici U, Kesici S, Ulusoy H, Yucesan F, Turkmen AU, Besir A, Tuna V, et al.
International wound journal. Date of publication 2015 Jun 1;volume 12(3):280-4.
1. Int Wound J. 2015 Jun;12(3):280-4. doi: 10.1111/iwj.12098. Epub 2013 Jun 6.
Effects of glutamine on wound healing.
Kesici U(1), Kesici S(2), Ulusoy H(3), Yucesan F(4), Turkmen AU(5), Besir A(3),
Tuna V(2).
Author information:
(1)Department of General Surgery, Akcaabat Hackali Baba State Hospital, Trabzon,
Turkey.
(2)Department of Anesthesiology and Reanimation, Kanuni Training and Research
Hospital, Trabzon, Turkey.
(3)Department of Anesthesiology and Reanimation, Faculty of Medicine, Karadeniz
Technical University, Trabzon, Turkey.
(4)Department of Biochemistry, Faculty of Medicine, Karadeniz Technical
University, Trabzon, Turkey.
(5)Department of Anesthesiology and Reanimation, Okmeydani Training and Research
Hospital, Istanbul, Turkey.
Studies reporting the need for replacing amino acids such as glutamine (Gln),
hydroxymethyl butyrate (HMB) and arginine (Arg) to accelerate wound healing are
available in the literature. The primary objective of this study was to present
the effects of Gln on tissue hydroxyproline (OHP) levels in wound healing. This
study was conducted on 30 female Sprague Dawley rats with a mean weight of 230 ±
20 g. Secondary wounds were formed by excising 2 × 1 cm skin subcutaneous tissue
on the back of the rats. The rats were divided into three equal groups. Group C
(Control): the group received 1 ml/day isotonic solution by gastric gavage after
secondary wound was formed. Group A (Abound): the group received 0·3 g/kg/day/ml
Gln, 0·052 g/kg/day/ml HMB and 0·3 g/kg/day/ml Arg by gastric gavage after
secondary wound was formed. Group R (Resource): the group received 0·3
g/kg/day/ml Gln by gastric gavage after secondary wound was formed. The OHP
levels of the tissues obtained from the upper half region on the 8th day and the
lower half region on the 21st day from the same rats in the groups were examined.
Statistical analysis was performed using the statistics program SPSS version
17.0. No statistically significant differences were reported with regard to the
OHP measurements on the 8th and 21st days (8th day: F = 0·068, P = 0·935 > 0·05;
21st day: F = 0·018, P = 0·983 > 0·05). The increase in mean OHP levels on the
8th and 21st days within each group was found to be statistically significant (F
= 1146·34, P = 0·000 < 0·001). We conclude that in adults who eat healthy food,
who do not have any factor that can affect wound healing negatively and who do
not have large tissue loss at critical level, Gln, Arg and HMB support would not
be required to accelerate secondary wound healing.
© 2013 The Authors. International Wound Journal © 2013 Medicalhelplines.com Inc
and John Wiley & Sons Ltd.
DOI: 10.1111/iwj.12098
PMID: 23738714 [Indexed for MEDLINE]
