Karalis M, Pavlidis TE, Psarras K, Ballas K, Zaraboukas T, Rafailidis S, Symeonidis N, Marakis GN, Sakantamis AK, et al.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europe.... Date of publication 2008 Jan 1;volume 40(2):190-6.
1. Eur Surg Res. 2008;40(2):190-6. Epub 2007 Nov 12.
Effect of experimentally induced liver cirrhosis on wound healing of the
post-extraction tooth socket in rats.
Karalis M(1), Pavlidis TE, Psarras K, Ballas K, Zaraboukas T, Rafailidis S,
Symeonidis N, Marakis GN, Sakantamis AK.
Author information:
(1)Second Propedeutical Department of Surgery, Medical School, Aristotle
University, Hippocration Hospital, Thessaloniki, Greece.
BACKGROUND: Wound healing in liver cirrhosis is known to be impaired possibly due
to liver insufficiency and subsequent malnutrition status; however, there is no
study to examine healing effectiveness of the tooth socket following an
extraction in such patients.
MATERIALS AND METHODS: Irreversible cirrhosis was induced in 30 Wistar rats by
repetitive weekly doses of CCl(4) and continuous administration of phenobarbital
in a 12-week course was monitored by body weight measurement and ascites
development, and was proved histologically. One week later, cirrhotic and control
rats were subjected to extractions of two maxillary grinders on each side, one
side by simple method, the other by surgical method. Half of the animals of each
subgroup were sacrificed on the 10th post-extraction day, whereas the other half
on the 30th post-extraction day, and histological sections were examined from all
tooth sockets for wound-healing activity.
RESULTS: A malnutrition status was detected in cirrhotic rats with significant
difference in their body weight. Several histological parameters of socket
healing were not statistically different between cirrhotic and control animals.
However, a significant delay on epithelialization and cancellous bone formation
was detected on the 10th post-extraction day for either simple or surgical
extractions in cirrhotic animals.
CONCLUSIONS: Liver cirrhosis in rats provokes a significant delay on
epithelialization and mature cancellous bone formation and consecutively on early
socket wound healing after a tooth extraction.
Copyright 2008 S. Karger AG, Basel.
DOI: 10.1159/000110860
PMID: 17998778 [Indexed for MEDLINE]
