Rodríguez-Morán M, Guerrero-Romero F, et al.
Archives of medical research. Date of publication 2001 Jul 1;volume 32(4):300-3.
1. Arch Med Res. 2001 Jul-Aug;32(4):300-3.
Low serum magnesium levels and foot ulcers in subjects with type 2 diabetes.
Rodríguez-Morán M(1), Guerrero-Romero F.
Author information:
(1)Unidad de Investigación Médica en Epidemiología Clínica, Hospital General,
Instituto Mexicano del Seguro Social (IMSS), Durango, Mexico.
rodriguez_moran@hotmail.com
BACKGROUND: Hypomagnesemia is associated with the development of neuropathy and
abnormal platelet activity, both of which are risk factors for the progression of
ulcers of the feet. Thus, the aim of this study was to determine the relationship
between low serum magnesium and foot ulcer in subjects with type 2 diabetes.
METHODS: Thirty-three out-patients with type 2 diabetes and foot ulcers (16 women
and 17 men) were compared with a control group of 66 out-patients with type 2
diabetes without foot ulcers (35 women and 31 men), matched by age, diabetes
duration, HbA1c, and glycemia. Patients with foot ulcers were included in the
study only if a foot ulceration onset not exceeding 2 months was established.
Patients diagnosed with reduced renal function, a history of alcohol intake, or
as having received magnesium supplementation or diuretics were not included.
Serum magnesium was measured by colorimetric method. The relationship between
serum magnesium and foot ulcers was assessed by logistic regression.
RESULTS: Hypomagnesemia was identified in 31 (93.9%) subjects with foot ulcers,
and 49 (73.1%) control subjects, p = 0.02. Subjects with foot ulceration had
lower serum magnesium levels (1.48 +/- 0.33) than those in the control group
(1.68 +/- 0.32), p <0.001. Logistic regression analysis showed a significant
relationship between low serum magnesium levels and foot ulcers (odds ratio [OR]
2.9, CI 95% 1.7-6.8; p = 0.01).
CONCLUSIONS: Serum magnesium depletion is present and shows a strong relationship
with foot ulcers in subjects with type 2 diabetes and foot ulcers, a relationship
not previously reported.
DOI: 10.1016/s0188-4409(01)00298-3
PMID: 11440788 [Indexed for MEDLINE]
