Kavros SJ, Miller JL, Hanna SW, et al.
Advances in skin & wound care. Date of publication 2007 Apr 1;volume 20(4):221-6.
1. Adv Skin Wound Care. 2007 Apr;20(4):221-6.
Treatment of ischemic wounds with noncontact, low-frequency ultrasound: the Mayo
clinic experience, 2004-2006.
Kavros SJ(1), Miller JL, Hanna SW.
Author information:
(1)Mayo Clinic College of Medicine, Rochester, MN, USA.
OBJECTIVE: To evaluate the clinical role of a novel, noncontact, low-intensity,
low-frequency ultrasound therapy (MIST Therapy) in the treatment of nonhealing
leg and foot ulcers associated with chronic critical limb ischemia.
DESIGN: Prospective, parallel-group, randomized, controlled trial.
SETTING: A multidisciplinary, vascular wound-healing clinic.
PATIENTS: Thirty-five patients who received MIST Therapy plus the standard of
wound care (treatment group) and 35 patients who received the standard of wound
care alone (control group).
INTERVENTIONS: Standard of wound care alone or standard of wound care plus MIST
Therapy for 12 weeks or until fully healed. MIST Therapy was administered 3 times
per week for 5 minutes per treatment.
MAIN OUTCOME MEASURE: Percentage of patients with greater than 50% reduction in
wound size from the index measurement after 12 weeks of treatment. The
relationship of transcutaneous oximetry pressure in the supine and dependent
position was evaluated as a factor in assessing the potential to heal ischemic
ulcerations of the foot and leg.
MAIN RESULTS: A significantly higher percentage of patients treated with the
standard of care plus MIST Therapy achieved greater than 50% wound healing at 12
weeks than those treated with the standard of care alone (63% vs 29%; P < .001).
Thus, failure to achieve the minimum wound healing requirement occurred in 37% of
patients in the treatment group and 71% of patients in the control group. The
predictive value of baseline transcutaneous oxygen pressure may benefit the
clinician when assessing the potential to heal ischemic wounds.
CONCLUSION: The rate of healing of cutaneous foot and leg ulcerations in patients
with chronic critical limb ischemia improved significantly when MIST Therapy was
combined with the standard of wound care.
DOI: 10.1097/01.ASW.0000266660.88900.38
PMID: 17415030 [Indexed for MEDLINE]
