Kashiwakura J, Otani IM, Kawakami T, et al.
Advances in experimental medicine and biology. Date of publication 2011 Jan 1;volume 716():29-46.
1. Adv Exp Med Biol. 2011;716:29-46. doi: 10.1007/978-1-4419-9533-9_3.
Monomeric IgE and mast cell development, survival and function.
Kashiwakura J(1), Otani IM, Kawakami T.
Author information:
(1)Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La
Jolla, California, USA.
Mast cells play a major role in allergy and anaphylaxis, as well as a protective
role in immunity against bacteria and venoms (innate immunity) and T-cell
activation (acquired immunity).1,2 It was long thought that two steps are
essential to mast cell activation. The first step (sensitization) occurs when
antigen-specific IgE binds to its high-affinity IgE receptor (FcεRI) expressed on
the surface of mast cells. The second step occurs when antigen (Ag) or anti-IgE
binds antigen-specific IgE antibodies bound to FcεRI present on the mast cell
surface (this mode of stimulation hereafter referred to as IgE+Ag or IgE+anti-IgE
stimulation, respectively).Conventional wisdom has been that monomeric IgE plays
only an initial, passive role in mast cell activation. However, recent findings
have shown that IgE binding to its receptor FcεRI can mediate mast cell
activation events even in the absence of antigen (this mode of stimulation
hereafter referred to as IgE(-Ag) stimulation). Different subtypes of monomeric
IgEs act via IgE(-Ag) stimulation to elicit varied effects on mast cells
function, survival and differentiation. This chapter will describe the role of
monomeric IgE molecules in allergic reaction, the various effects and mechanisms
of action of IgE(-Ag) stimulation on mast cells and what possible developments
may arise from this knowledge in the future. Since mast cells are involved in a
variety of pathologic and protective responses, understanding the role that
monomeric IgE plays in mast cell function, survival and differentiation will
hopefully lead to better understanding and treatment of asthma and other allergic
diseases, as well as improved understanding of host response to infections.
DOI: 10.1007/978-1-4419-9533-9_3
PMID: 21713650 [Indexed for MEDLINE]
