Yang R, Liu F, Wang J, Chen X, Xie J, Xiong K, et al.
Stem cell research & therapy. Date of publication 2019 Jul 29;volume 10(1):229.
1. Stem Cell Res Ther. 2019 Jul 29;10(1):229. doi: 10.1186/s13287-019-1312-z.
Epidermal stem cells in wound healing and their clinical applications.
Yang R(1), Liu F(2), Wang J(1), Chen X(1), Xie J(3), Xiong K(4).
Author information:
(1)Department of Burn Surgery, The First People's Hospital of Foshan, Foshan,
528000, China.
(2)Department of Human Anatomy, School of Basic Medical Science, Xinjiang Medical
University, Urumqi, 830001, China.
(3)Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen
University, Guangzhou, 512100, China. sysxiejl90@sohu.com.
(4)Department of Anatomy and Neurobiology, School of Basic Medical Science,
Morphological Sciences Building, Central South University, 172 Tongzi Po Road,
Changsha, 410013, Hunan, China. xiongkun2001@163.com.
The skin has important barrier, sensory, and immune functions, contributing to
the health and integrity of the organism. Extensive skin injuries that threaten
the entire organism require immediate and effective treatment. Wound healing is a
natural response, but in severe conditions, such as burns and diabetes, this
process is insufficient to achieve effective treatment. Epidermal stem cells
(EPSCs) are a multipotent cell type and are committed to the formation and
differentiation of the functional epidermis. As the contributions of EPSCs in
wound healing and tissue regeneration have been increasingly attracting the
attention of researchers, a rising number of therapies based on EPSCs are
currently under development. In this paper, we review the characteristics of
EPSCs and the mechanisms underlying their functions during wound healing.
Applications of EPSCs are also discussed to determine the potential and
feasibility of using EPSCs clinically in wound healing.
DOI: 10.1186/s13287-019-1312-z
PMCID: PMC6664527
PMID: 31358069 [Indexed for MEDLINE]
