Teunissen MB, Haniffa M, Collin MP, et al.
Current topics in microbiology and immunology. Date of publication 2012 Jan 1;volume 351():25-76.
1. Curr Top Microbiol Immunol. 2012;351:25-76. doi: 10.1007/82_2011_169.
Insight into the immunobiology of human skin and functional specialization of
skin dendritic cell subsets to innovate intradermal vaccination design.
Teunissen MB(1), Haniffa M, Collin MP.
Author information:
(1)Department of Dermatology, Academic Medical Center, University of Amsterdam,
Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. m.b.teunissen@amc.uva.nl
Dendritic cells (DC) are the key initiators and regulators of any immune response
which determine the outcome of CD4(+) and CD8(+) T-cell responses. Multiple
distinct DC subsets can be distinguished by location, phenotype, and function in
the homeostatic and inflamed human skin. The function of steady-state cutaneous
DCs or recruited inflammatory DCs is influenced by the surrounding cellular and
extracellular skin microenvironment. The skin is an attractive site for
vaccination given the extended local network of DCs and the easy access to the
skin-draining lymph nodes to generate effector T cells and
immunoglobulin-producing B cells for long-term protective immunity. In the
context of intradermal vaccination we describe in this review the skin-associated
immune system, the characteristics of the different skin DC subsets, the
mechanism of antigen uptake and presentation, and how the properties of DCs can
be manipulated. This knowledge is critical for the development of intradermal
vaccine strategies and supports the concept of intradermal vaccination as a
superior route to the conventional intramuscular or subcutaneous methods.
DOI: 10.1007/82_2011_169
PMID: 21833835 [Indexed for MEDLINE]
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