Denda M, Tsutsumi M, et al.
Advances in experimental medicine and biology. Date of publication 2011 Jan 1;volume 704():847-60.
1. Adv Exp Med Biol. 2011;704:847-60. doi: 10.1007/978-94-007-0265-3_44.
Roles of transient receptor potential proteins (TRPs) in epidermal keratinocytes.
Denda M(1), Tsutsumi M.
Author information:
(1)Shiseido Research Center, Yokohama, Kanagawa 236-8643, Japan.
mitsuhiro.denda@to.shiseido.co.jp
Epidermal keratinocytes are the epithelial cells of mammalian skin. At the basal
layer of the epidermis, these cells proliferate strongly, and as they move
towards the skin surface, differentiation proceeds. At the uppermost layer of the
epidermis, keratinocytes undergo apoptosis and die, forming a thin,
water-impermeable layer called the stratum corneum. Peripheral blood vessels do
not reach the epidermis, but peripheral nerve fibers do penetrate into it. Until
recently, it was considered that the main role of epidermal keratinocytes was to
construct and maintain the water-impermeable barrier function. However, since the
functional existence of TRPV1, which is activated by heat and low pH, in
epidermal keratinocytes was identified, our understanding of the role of
keratinocytes has changed enormously. It has been found that many TRP channels
are expressed in epidermal keratinocytes, and play important roles in
differentiation, proliferation and barrier homeostasis. Moreover, because TRP
channels expressed in keratinocytes have the ability to sense a variety of
environmental factors, such as temperature, mechanical stress, osmotic stress and
chemical stimuli, epidermal keratinocytes might form a key part of the sensory
system of the skin. The present review deals with the potential roles of TRP
channels expressed in epidermal keratinocytes and focuses on the concept of the
epidermis as an active interface between the body and the environment.
DOI: 10.1007/978-94-007-0265-3_44
PMID: 21290330 [Indexed for MEDLINE]
