Xiao T, Yan Z, Xiao S, Xia Y, et al.
Stem cell research & therapy. Date of publication 2020 Jun 11;volume 11(1):232.
1. Stem Cell Res Ther. 2020 Jun 11;11(1):232. doi: 10.1186/s13287-020-01755-y.
Proinflammatory cytokines regulate epidermal stem cells in wound
epithelialization.
Xiao T(1), Yan Z(1), Xiao S(1), Xia Y(2).
Author information:
(1)Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong
University, 157 Xiwu Road, Xi'an, 710004, China.
(2)Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong
University, 157 Xiwu Road, Xi'an, 710004, China. xiayumin1202@163.com.
The skin, which serves as the first barrier of the human body, is particularly
susceptible to exogenous injuries. Skin wounds, including acute burns and chronic
non-healing ulcers, are commonly observed in clinics. Healing of skin wounds is a
complex process, consisting of infiltration of inflammatory cells, cellular
proliferation, and tissue remodeling phases, which restore the integrity and
functions of the skin. Epithelialization is involved in wound healing through
re-establishing an intact keratinocyte layer. Epidermal stem cells are
indispensable for epithelialization, and they are regulated by multiple
proinflammatory cytokines or growth factors. In this review, we summarize recent
advances in the effect of these cytokines on migration, proliferation, and
differentiation processes of epidermal stem cells. We also introduce promising
therapeutic strategies targeting epidermal stem cells or related proinflammatory
cytokines for patients with skin wounds.
DOI: 10.1186/s13287-020-01755-y
PMCID: PMC7291661
PMID: 32527289
