WoundReference improves clinical decisions
 Choose the role that best describes you
Xiao T, Yan Z, Xiao S, Xia Y, et al.
Stem cell research & therapy. Date of publication 2020 Jun 11;volume 11(1):232.
1. Stem Cell Res Ther. 2020 Jun 11;11(1):232. doi: 10.1186/s13287-020-01755-y. Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization. Xiao T(1), Yan Z(1), Xiao S(1), Xia Y(2). Author information: (1)Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China. (2)Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China. xiayumin1202@163.com. The skin, which serves as the first barrier of the human body, is particularly susceptible to exogenous injuries. Skin wounds, including acute burns and chronic non-healing ulcers, are commonly observed in clinics. Healing of skin wounds is a complex process, consisting of infiltration of inflammatory cells, cellular proliferation, and tissue remodeling phases, which restore the integrity and functions of the skin. Epithelialization is involved in wound healing through re-establishing an intact keratinocyte layer. Epidermal stem cells are indispensable for epithelialization, and they are regulated by multiple proinflammatory cytokines or growth factors. In this review, we summarize recent advances in the effect of these cytokines on migration, proliferation, and differentiation processes of epidermal stem cells. We also introduce promising therapeutic strategies targeting epidermal stem cells or related proinflammatory cytokines for patients with skin wounds. DOI: 10.1186/s13287-020-01755-y PMCID: PMC7291661 PMID: 32527289
Appears in following Topics:
The Skin