Hwa C, Bauer EA, Cohen DE, et al.
Dermatologic therapy. Date of publication 2011 Sep 1;volume 24(5):464-70.
1. Dermatol Ther. 2011 Sep-Oct;24(5):464-70. doi: 10.1111/j.1529-8019.2012.01460.x.
Skin biology.
Hwa C(1), Bauer EA, Cohen DE.
Author information:
(1)Ronald O Perelman Department of Dermatology, New York University School of
Medicine, 550 First Avenue, New York, NY 10016, USA.
The development of topical drug delivery systems has recently gained significant
interest due to the ease of administration and lesser risks of systemic toxicity.
The development of these new technologies utilizes the properties of the
structure and function of the skin. The stratum corneum plays the largest role in
affecting drug permeation, as the corneocytes and lipid matrix in this layer
effectively prevent the diffusion of large molecules. In this review, we
introduce the structure and function of the skin as it relates to topical drug
delivery.
© 2012 Wiley Periodicals, Inc.
DOI: 10.1111/j.1529-8019.2012.01460.x
PMID: 22353152 [Indexed for MEDLINE]
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