Werner S, Grose R, et al.
Physiological reviews. Date of publication 2003 Jul 1;volume 83(3):835-70.
1. Physiol Rev. 2003 Jul;83(3):835-70.
Regulation of wound healing by growth factors and cytokines.
Werner S(1), Grose R.
Author information:
(1)Institute of Cell Biology, ETH Zurich, Hönggerberg, HPM D42, CH-8093 Zurich,
Switzerland. sabine.werner@cell.biol.ethz.ch
Cutaneous wound healing is a complex process involving blood clotting,
inflammation, new tissue formation, and finally tissue remodeling. It is well
described at the histological level, but the genes that regulate skin repair have
only partially been identified. Many experimental and clinical studies have
demonstrated varied, but in most cases beneficial, effects of exogenous growth
factors on the healing process. However, the roles played by endogenous growth
factors have remained largely unclear. Initial approaches at addressing this
question focused on the expression analysis of various growth factors, cytokines,
and their receptors in different wound models, with first functional data being
obtained by applying neutralizing antibodies to wounds. During the past few
years, the availability of genetically modified mice has allowed elucidation of
the function of various genes in the healing process, and these studies have shed
light onto the role of growth factors, cytokines, and their downstream effectors
in wound repair. This review summarizes the results of expression studies that
have been performed in rodents, pigs, and humans to localize growth factors and
their receptors in skin wounds. Most importantly, we also report on genetic
studies addressing the functions of endogenous growth factors in the wound repair
process.
DOI: 10.1152/physrev.2003.83.3.835
PMID: 12843410 [Indexed for MEDLINE]
