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Kullo IJ, Leeper NJ, et al.
Circulation research. Date of publication 2015 Apr 24;volume 116(9):1551-60.
1. Circ Res. 2015 Apr 24;116(9):1551-60. doi: 10.1161/CIRCRESAHA.116.303518. The genetic basis of peripheral arterial disease: current knowledge, challenges, and future directions. Kullo IJ(1), Leeper NJ(2). Author information: (1)From the Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (I.J.K.); and Department of Vascular Surgery, Stanford, Stanford, CA (N.J.L.). kullo.iftikhar@mayo.edu. (2)From the Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (I.J.K.); and Department of Vascular Surgery, Stanford, Stanford, CA (N.J.L.). Several risk factors for atherosclerotic peripheral arterial disease (PAD), such as dyslipidemia, diabetes mellitus, and hypertension, are heritable. However, predisposition to PAD may be influenced by genetic variants acting independently of these risk factors. Identification of such genetic variants will provide insights into underlying pathophysiologic mechanisms and facilitate the development of novel diagnostic and therapeutic approaches. In contrast to coronary heart disease, relatively few genetic variants that influence susceptibility to PAD have been discovered. This may be, in part, because of greater clinical and genetic heterogeneity in PAD. In this review, we (1) provide an update on the current state of knowledge about the genetic basis of PAD, including results of family studies and candidate gene, linkage as well as genome-wide association studies; (2) highlight the challenges in investigating the genetic basis of PAD and possible strategies to overcome these challenges; and (3) discuss the potential of genome sequencing, RNA sequencing, differential gene expression, epigenetic profiling, and systems biology in increasing our understanding of the molecular genetics of PAD. © 2015 American Heart Association, Inc. DOI: 10.1161/CIRCRESAHA.116.303518 PMCID: PMC4410432 PMID: 25908728 [Indexed for MEDLINE]
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Arterial Ulcer - Introduction and Assessment
How to Assess a Patient with Chronic Wounds