Goodall R, Salciccioli JD, Davies AH, Marshall D, Shalhoub J, et al.
European journal of preventive cardiology. Date of publication 2020 Feb 3;volume ():2047487319899626.
1. Eur J Prev Cardiol. 2020 Feb 3:2047487319899626. doi: 10.1177/2047487319899626.
[Epub ahead of print]
Trends in peripheral arterial disease incidence and mortality in EU15+ countries
1990-2017.
Goodall R(1)(2), Salciccioli JD(3), Davies AH(1)(2), Marshall D(4), Shalhoub
J(1)(2).
Author information:
(1)Academic Section of Vascular Surgery, Department of Surgery and Cancer,
Imperial College London, UK.
(2)Department of Vascular Surgery, Imperial College Healthcare NHS Trust, London,
UK.
(3)Department of Medicine, Mount Auburn Hospital, Harvard Medical School,
Cambridge, MA, USA.
(4)Critical Care Research Group, Nuffield Department of Clinical Neurosciences,
University of Oxford, UK.
AIMS: The aim was to assess trends in peripheral arterial disease (PAD) incidence
and mortality rates in European Union(15+) countries between 1990 and 2017.
METHODS AND RESULTS: This observational study used data obtained from the 2017
Global Burden of Disease study. Age-standardised mortality and incidence rates
from PAD were extracted from the Global Health Data Exchange for EU15+ countries
for the years 1990-2017. Trends were analysed using Joinpoint regression
analysis. Between 1990 and 2017, the incidence of PAD decreased in all 19 EU15+
countries for females, and in 18 of 19 countries for males. Increasing PAD
incidence was observed only for males in the United States (+1.4%). In 2017, the
highest incidence rates were observed in Denmark and the United States for males
(213.6 and 202.3 per 100,000, respectively) and in the United States and Canada
for females (194.8 and 171.1 per 100,000, respectively). There was a concomitant
overall trend for increasing age-standardised mortality rates in all EU15+
countries for females, and in 16 of 19 EU15+ countries for males between 1990 and
2017. Italy (-25.1%), Portugal (-1.9%) and Sweden (-0.6%) were the only countries
with reducing PAD mortality rates in males. The largest increases in mortality
rates were observed in the United Kingdom (males +140.4%, females +158.0%) and
the United States (males +125.7%, females +131.2%).
CONCLUSIONS: We identify shifting burden of PAD in EU15+ countries, with
increasing mortality rates despite reducing incidence. Strong evidence supports
goal-directed medical therapy in reducing PAD mortality - population-wide
strategies to improve compliance to optimal goal-directed medical therapy are
warranted.
DOI: 10.1177/2047487319899626
PMID: 32013595
