Levin SR, Arinze N, Siracuse JJ, et al.
Trends in cardiovascular medicine. Date of publication 2020 Apr 1;volume 30(3):125-130.
1. Trends Cardiovasc Med. 2020 Apr;30(3):125-130. doi: 10.1016/j.tcm.2019.04.002.
Epub 2019 Apr 15.
Lower extremity critical limb ischemia: A review of clinical features and
management.
Levin SR(1), Arinze N(1), Siracuse JJ(2).
Author information:
(1)Division of Vascular and Endovascular Surgery, Boston University School of
Medicine, Boston Medical Center, 88 E. Newton Street C520, Boston, MA 02118,
United States.
(2)Division of Vascular and Endovascular Surgery, Boston University School of
Medicine, Boston Medical Center, 88 E. Newton Street C520, Boston, MA 02118,
United States. Electronic address: jeffrey.siracuse@bmc.org.
Lower extremity critical limb ischemia (CLI) represents symptoms related to
end-stage atherosclerotic peripheral arterial disease manifested by rest pain and
tissue loss. It is associated with increased risk of limb amputation and
cardiovascular-related mortality. The prevalence and cost of CLI are expected to
increase with both the aging of the U.S. population and continued influence of
smoking and diabetes. Treatments encompass measures to reduce cardiovascular risk
and preserve limb viability. Despite increasing popularity of endovascular
modalities, revascularization with either surgical bypass or endovascular
intervention is the cornerstone of therapy. Adequate Level I data to guide
decisions regarding optimal strategies to treat CLI, particularly in patients who
are candidates for both open and percutaneous approaches, are currently lacking.
Ongoing randomized controlled trials aim to resolve the clinical equipoise.
Copyright © 2019 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.tcm.2019.04.002
PMID: 31005554
