Schneider KL, Yahia N, et al.
Advances in skin & wound care. Date of publication 2019 Oct 1;volume 32(10):457-462.
1. Adv Skin Wound Care. 2019 Oct;32(10):457-462. doi:
10.1097/01.ASW.0000579700.20404.56.
Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in
Acute and Chronic Settings: A Systematic Review.
Schneider KL(1), Yahia N.
Author information:
(1)Kara L. Schneider, MS, RD, LD, is Clinical Nutrition Manager, TouchPoint
Support Services, Washington, DC; and Najat Yahia, PhD, MS, RD, LD, is Professor,
Department of Human Environmental Services, Dietetics, and Nutrition, Central
Michigan University, Mount Pleasant, Michigan. The authors have disclosed no
financial relationships related to this article. Submitted November 15, 2018;
accepted in revised form January 4, 2019.
OBJECTIVE: To examine the effect of arginine supplementation on wound healing, as
measured by wound size and healing rate, in older adults in acute and long-term
care (LTC) settings.
DATA SOURCES: PubMed, CINAHL Plus, Google Scholar, and OpenGrey databases.
STUDY SELECTION: Randomized clinical trials and clinical studies were considered
for this review. Selection criteria included English-language articles published
after 2008 that provide data on older adults with pressure injury receiving
arginine supplementation in acute care and LTC settings.
DATA EXTRACTION: Data were extracted from the articles using a predefined
checklist including study size and design, participant characteristics (age,
pressure injury stage, relevant comorbidities), nutrition intervention and
dosage, duration of study, outcomes, and publication year. Studies were appraised
using the National Institutes of Health's Quality Assessment of Controlled
Intervention Studies tool.
DATA SYNTHESIS: A preliminary search yielded 39 articles after removing
duplicates. Abstracts and titles of articles were screened, and 23 full-text
articles were examined further. Ultimately, six articles met the inclusion
criteria.
CONCLUSIONS: Current evidence suggests that arginine supplementation in
conjunction with oral nutrition supplementation may promote wound healing in
older adult patients in acute care and LTC settings as evidenced by significant
reductions in wound size and improvements in wound healing when compared with
oral nutrition supplementation alone. A definitive conclusion about the use of
arginine supplementation alone to promote wound healing cannot be drawn because
of limitations in the available literature. Additional high-quality studies are
needed to examine arginine supplementation alone as a potential therapy for PI.
DOI: 10.1097/01.ASW.0000579700.20404.56
PMID: 31498170
