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Hazra A, Kraft P, Selhub J, Giovannucci EL, Thomas G, Hoover RN, Chanock SJ, Hunter DJ, et al.
Nature genetics. Date of publication 2008 Oct 1;volume 40(10):1160-2.
1. Nat Genet. 2008 Oct;40(10):1160-2. doi: 10.1038/ng.210. Epub 2008 Sep 7. Common variants of FUT2 are associated with plasma vitamin B12 levels. Hazra A(1), Kraft P, Selhub J, Giovannucci EL, Thomas G, Hoover RN, Chanock SJ, Hunter DJ. Author information: (1)Department of Epidemiology, Harvard School of Public Health, Program in Molecular and Genetic Epidemiology, Boston, Massachusetts 02115, USA. We identified a strong association (P = 5.36 x 10(-17)) between rs492602 in FUT2 and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels. DOI: 10.1038/ng.210 PMCID: PMC2673801 PMID: 18776911 [Indexed for MEDLINE]
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Patient Education - Nutrition for wound healing in action - Step 1: Map out your meals
Patient Education - Nutrition for wound healing in action - Step 2: Leverage supplements