Avishai E, Yeghiazaryan K, Golubnitschaja O, et al.
The EPMA journal. Date of publication 2017 Mar 3;volume 8(1):23-33.
1. EPMA J. 2017 Mar 3;8(1):23-33. doi: 10.1007/s13167-017-0081-y. eCollection 2017
Mar.
Impaired wound healing: facts and hypotheses for multi-professional
considerations in predictive, preventive and personalised medicine.
Avishai E(1), Yeghiazaryan K(2), Golubnitschaja O(2).
Author information:
(1)Rappaport Faculty of Medicine, Technion, Haifa, Israel.
(2)Radiological Clinic, Medical Faculty, Friedrich-Wilhels-University of Bonn,
Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
Whereas the physiologic wound healing (WH) successfully proceeds through the
clearly defined sequence of the individual phases of wound healing, chronic
non-healing wounds/ulcers fail to complete the individual stages and the entire
healing process. There are many risk factors both modifiable (such as stress,
smoking, inappropriate alcohol consumption, malnutrition, obesity, diabetes,
cardio-vascular disease, etc.) and non-modifiable (such as genetic diseases and
ageing) strongly contributing to the impaired WH. Current statistics demonstrate
that both categories are increasingly presented in the populations, which causes
dramatic socio-economic burden to the healthcare sector and society at large.
Consequently, innovative concepts by predictive, preventive and personalised
medicine are crucial to be implemented in the area. Individual risk factors,
causality, functional interrelationships, molecular signature, predictive
diagnosis, and primary and secondary prevention are thoroughly analysed followed
by the expert recommendations in this paper.
DOI: 10.1007/s13167-017-0081-y
PMCID: PMC5471802
PMID: 28620441
