Author(s) Thom SR

Journal Toxicology and applied pharmacology. Date of publication 1990 Sep 1;volume 105(2):340-4.

Abstract 1. Toxicol Appl Pharmacol. 1990 Sep 1;105(2):340-4. Antagonism of carbon monoxide-mediated brain lipid peroxidation by hyperbaric oxygen. Thom SR(1). Author information: (1)Institute for Environmental Medicine, University of Pennsylvania, Philadelphia 19104-6068. The effects of oxygen at 1, 2, and 3, atmospheres absolute (ATA) were assessed on brain lipid peroxidation caused by carbon monoxide (CO) poisoning in a rat model. Oxygen at 3 ATA, but not 1 ATA, was found to prevent brain lipid peroxidation when administered to rats for 45 min, beginning 45 min subsequent to CO poisoning. Oxygen at 2 ATA had an intermediate effect. The action of hyperbaric oxygen could not be attributed to a more rapid diminution of carboxyhemoglobin, and appears to occur at the level of the brain tissue. DOI: 10.1016/0041-008x(90)90195-z PMID: 2219124 [Indexed for MEDLINE]

Source ID (e.g. PMID): 2219124