WoundReference improves clinical decisions
 Choose the role that best describes you
Lin CH, Su WH, Chen YC, Feng PH, Shen WC, Ong JR, Wu MY, Wong CS, et al.
Medicine. Date of publication 2018 Sep 1;volume 97(39):e12456.
1. Medicine (Baltimore). 2018 Sep;97(39):e12456. doi: 10.1097/MD.0000000000012456. Treatment with normobaric or hyperbaric oxygen and its effect on neuropsychometric dysfunction after carbon monoxide poisoning: A systematic review and meta-analysis of randomized controlled trials. Lin CH(1), Su WH(2), Chen YC(3), Feng PH(4)(5), Shen WC(3), Ong JR(6)(7), Wu MY(5)(8)(9), Wong CS(6)(7)(10). Author information: (1)School of Medicine, College of Medicine, Taipei Medical University. (2)Department of Otolaryngology, Head and Neck Surgery, Chimei Medical Center. (3)Department of Pharmacy. (4)Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital. (5)Department of Internal Medicine, School of Medicine, College of Medicine. (6)Emergency Department, Shuang Ho Hospital. (7)Department of Emergency, School of Medicine. (8)Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University. (9)Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University. (10)Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. BACKGROUND: Carbon monoxide (CO) poisoning may result in acute neurological sequelae, cognitive sequelae, and delay neurological sequelae. The administration of hyperbaric oxygen (HBO) to prevent the development of delayed neurological sequelae in CO poisoning have extensively investigated but conflicting results have been reported. We performed a systematic literature review and meta-analysis of randomized controlled trials (RCTs) evaluating HBO treatment and its effect on neuropsychometric dysfunction after CO poisoning. METHODS: We searched Medline, Embase, Pubmed, and the Cochrane Register of Controlled Trials from inception to December 2017. Eligible studies compared HBO therapy with normobaric oxygen (NBO) in patients with CO poisoning. RESULTS: Six studies compared HBO with NBO in CO poisoning patients. Compared with patients treated with NBO, a lower percentage of patients treated with HBO reported headache (16.2% vs 16.5%, relative risk [RR] = 0.83, 95% CI = 0.38-1.80), memory impairment (18.2% vs 23.8%, RR = 0.80, 95% CI = 0.43-1.49), difficulty concentrating (15.0% vs 18.4%, RR = 0.86, 95% CI = 0.55-1.34), and disturbed sleep (14.7% vs 16.2%, RR = 0.91, 95% CI = 0.59-1.39). Two sessions of HBO treatment exhibited no advantage over one session. CONCLUSIONS: The meta-analysis indicated that compared with CO poisoning patients treated with NBO, HBO treated patients have a lower incidence of neuropsychological sequelae, including headache, memory impairment, difficulty concentrating, disturbed sleep, and delayed neurological sequelae. Taking into consideration the cost-effectiveness of one session of HBO, one session of HBO treatment could be an economical option for patients with CO poisoning with high severity. DOI: 10.1097/MD.0000000000012456 PMCID: PMC6181555 PMID: 30278526 [Indexed for MEDLINE]
Appears in following Topics:
Acute Carbon Monoxide Poisoning