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Bekheit M, Baddour N, Katri K, Taher Y, El Tobgy K, Mousa E, et al.
BMJ open gastroenterology. Date of publication 2016 Apr 28;volume 3(1):e000082.
1. BMJ Open Gastroenterol. 2016 Apr 28;3(1):e000082. doi: 10.1136/bmjgast-2016-000082. eCollection 2016. Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative colitis: a prospective case series. Bekheit M(1), Baddour N(2), Katri K(3), Taher Y(4), El Tobgy K(5), Mousa E(3). Author information: (1)Department of Surgery, El Kabbary General Hospital, Alexandria, Egypt; Department of Surgery, Faculty of Medicine, Alexandria Main University Hospital, Alexandria, Egypt. (2)Department of Pathology, Faculty of Medicine , Alexandria Main University Hospital , Alexandria , Egypt. (3)Department of Surgery, Faculty of Medicine , Alexandria Main University Hospital , Alexandria , Egypt. (4)Department of Internal Medicine, Faculty of Medicine , Alexandria Main University Hospital , Alexandria , Egypt. (5)Department of Hyperbaric Medicine , Naval Hospital , Alexandria , Egypt. BACKGROUND: Hyperbaric oxygen (HBO) is used as part of treatment in a variety of clinical conditions. Its use in the treatment of ulcerative colitis has been reported in few clinical reports. OBJECTIVE: We report the effect of HBO on refractory ulcerative colitis exploring one potential mechanism of action. DESIGN: A review of records of patients with refractory ulcerative colitis who received HBO was conducted. Clinical and histopathological scoring was utilised to evaluate the response to HBO therapy (HBOT). RESULTS: All patients manifested clinical improvement by the 40th cycle of HBOT. The median number of stool frequency dropped from seven motions/day (range=3-20) to 1/day (range=0.5-3), which was significant (z=-4.6, p<0.001). None of the patients manifested persistent blood passage after HBOT (z=-3.2, p=0.002). The severity index significantly improved after HBOT (z=-4.97, p<0.001). Histologically, a significant reduction of the scores of activity was recorded accompanied by a significant increase in the proliferating cell nuclear antigen labelling index of the CD44 cells of the colonic mucosa (p=0.001). CONCLUSIONS: HBOT is effective in the setting of refractory ulcerative colitis. The described protocol is necessary for successful treatment. HBOT stimulates colonic stem cells to promote healing. DOI: 10.1136/bmjgast-2016-000082 PMCID: PMC4860723 PMID: 27195128
Appears in following Topics:
Investigational HBOT Indications - Inflammatory Bowel Disease
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