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Li Y, Dong H, Chen M, Liu J, Yang L, Chen S, Xiong L, et al.
Journal of cardiothoracic and vascular anesthesia. Date of publication 2011 Dec 1;volume 25(6):908-16.
1. J Cardiothorac Vasc Anesth. 2011 Dec;25(6):908-16. doi: 10.1053/j.jvca.2011.06.017. Epub 2011 Aug 25. Preconditioning with repeated hyperbaric oxygen induces myocardial and cerebral protection in patients undergoing coronary artery bypass graft surgery: a prospective, randomized, controlled clinical trial. Li Y(1), Dong H, Chen M, Liu J, Yang L, Chen S, Xiong L. Author information: (1)Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. OBJECTIVES: To evaluate the cerebral and myocardial protective effects of hyperbaric oxygen preconditioning in both on-pump and off-pump coronary artery bypass graft surgery. DESIGN: A prospective, randomized, single-blinded study including patients scheduled for elective on-pump or off-pump surgery between December 2007 and February 2009. SETTING: A tertiary care university teaching hospital. PARTICIPANTS: Forty-nine elective on-pump or off-pump coronary artery bypass graft surgery patients. INTERVENTIONS: Patients were randomized to either the control (15 patients with on-pump procedure and 10 patients with off-pump procedure, respectively) or hyperbaric oxygen (HBO; 14 patients with on-pump procedure and 10 patients with off-pump procedure, respectively) groups. Patients in the HBO groups underwent preconditioning for 5 days before surgery. MEASUREMENTS AND MAIN RESULTS: On-pump coronary artery bypass graft surgery patients preconditioned with HBO had significant decreases in S100B protein, neuron-specific enolase, and troponin I perioperative serum levels compared with the on-pump control group. Postsurgically, patients in the on-pump HBO group had a reduced length of stay in the intensive care unit and a decreased use of inotropic drugs. Serum catalase activity 24 hours postoperatively was significantly increased compared with the on-pump control group. In the off-pump groups, there was no difference in any of the same parameters. CONCLUSIONS: Preconditioning with HBO resulted in both cerebral and cardiac protective effects as determined by biochemical markers of neuronal and myocardial injury and clinical outcomes in patients undergoing on-pump coronary artery bypass graft surgery. No protective effects were noted in off-pump coronary artery bypass graft surgery. Copyright © 2011 Elsevier Inc. All rights reserved. DOI: 10.1053/j.jvca.2011.06.017 PMID: 21868252 [Indexed for MEDLINE]
Appears in following Topics:
Investigational HBOT Indications - Preconditioning for Cardiac Surgery