Jeysen ZY, Gerard L, Levant G, Cowen M, Cale A, Griffin S, et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, In.... Date of publication 2011 May 1;volume 38(3):175-85.
1. Undersea Hyperb Med. 2011 May-Jun;38(3):175-85.
Research report: the effects of hyperbaric oxygen preconditioning on myocardial
biomarkers of cardioprotection in patients having coronary artery bypass graft
surgery.
Jeysen ZY(1), Gerard L, Levant G, Cowen M, Cale A, Griffin S.
Author information:
(1)Department of Cardiothoracic Surgery, Castle Hill Hospital, Cottingham, United
Kingdom. jeysenzy@msn.com
We have previously conducted and reported on the primary endpoint of a clinical
study which demonstrated that hyperbaric oxygen (HBO2) preconditioning consisting
of two 30-minute intervals of 100% oxygen at 2.4 atmospheres absolute (ATA) prior
to coronary artery bypass graft (CABG) surgery leads to an improvement in left
ventricular stroke work (LVSW) 24 hours following CABG. In that study, 81
patients were randomized to treatment with HBO2 (HBO2; n = 41) or routine
treatment (Control Group; n = 40) prior to surgery. The objective of this
manuscript is to further report on the result of the exploratory secondary
endpoints from that study, specifically the effects of HBO2 preconditioning on
biomarkers of myocardial protection. Intraoperative right atrial biopsies were
assessed, via an Enzyme Linked ImmunoSorbent Assay (ELISA), for the expression of
eNOS and HSP72. In this study, no significant differences were observed between
the groups with respect to the quantity of myocardial eNOS and HSP72. However, in
the HBO2 Group, following ischemia and reperfusion, the quantities of myocardial
eNOS and HSP72 were increased. This suggests that HBO2 preconditioning in this
group of patients may be capable of inducing endogenous cardioprotection
following ischemic reperfusion injury (IRI).
PMID: 21721351 [Indexed for MEDLINE]
