Godman CA, Joshi R, Giardina C, Perdrizet G, Hightower LE, et al.
Annals of the New York Academy of Sciences. Date of publication 2010 Jun 1;volume 1197():178-83.
1. Ann N Y Acad Sci. 2010 Jun;1197:178-83. doi: 10.1111/j.1749-6632.2009.05393.x.
Hyperbaric oxygen treatment induces antioxidant gene expression.
Godman CA(1), Joshi R, Giardina C, Perdrizet G, Hightower LE.
Author information:
(1)Department of Molecular and Cell Biology, University of Connecticut, Storrs,
Connecticut, USA.
Although the underlying molecular causes of aging are not entirely clear,
hormetic agents like exercise, heat, and calorie restriction may generate a mild
pro-oxidant stress that induces cell protective responses to promote healthy
aging. As an individual ages, many cellular and physiological processes decline,
including wound healing and reparative angiogenesis. This is particularly
critical in patients with chronic non-healing wounds who tend to be older. We are
interested in the potential beneficial effects of hyperbaric oxygen as a mild
hormetic stress on human microvascular endothelial cells. We analyzed global gene
expression changes in human endothelial cells following a hyperbaric exposure
comparable to a clinical treatment. Our analysis revealed an upregulation of
antioxidant, cytoprotective, and immediate early genes. This increase coincided
with an increased resistance to a lethal oxidative stress. Our data indicate that
hyperbaric oxygen can induce protection against oxidative insults in endothelial
cells and may provide an easily administered hormetic treatment to help promote
healthy aging.
DOI: 10.1111/j.1749-6632.2009.05393.x
PMID: 20536847 [Indexed for MEDLINE]
