Mitrović A, Nikolić B, Dragojević S, Brkić P, Ljubić A, Jovanović T, et al.
Bosnian journal of basic medical sciences. Date of publication 2006 May 1;volume 6(2):21-4.
1. Bosn J Basic Med Sci. 2006 May;6(2):21-4.
Hyperbaric oxygenation as a possible therapy of choice for infertility treatment.
Mitrović A(1), Nikolić B, Dragojević S, Brkić P, Ljubić A, Jovanović T.
Author information:
(1)University Clinic of Gynecology and Obstetrics "Narodni front", Narodni front
62, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia and
Montenegro.
Endometrial sonographic and color doppler features can be used to predict the
occurrence of pregnancy in natural or stimulated cycles. Implantation will
usually only take place if the endometrium has reach a certain stage of
vascularisation and development. The aim of this study was to evaluate
endometrial development -- endometrial thickness and reflectivity ,
subendometrial, endometrial and uterine perfusion, after hyperbaric oxygenation,
using transvaginal color doppler. During a three years period 32 women with
unexplained infertility were entered into a randomised study. The patients were
treated in multiplaced HAUX chamber at pressure of 2.3 ATA during 70 minutes, 7
days consecutively beginning with day 5th of menstrual cycle. The evaluation of
effects of hyperbaric oxygen therapy was carried out by transvaginal color
doppler sonography which was continuously used starting from 8th day of menstrual
cycle until the ovulation in the cycles when the therapy was applied , one month
before and one month after the therapy. Folliculometry in the cycles when
hyperbaric oxygen therapy at 2.3 ATA was applied, indicated an excellent response
of endometrium. Thickness of endometrium at the time of ovulation was 11.0 +/-
2.6 mm. Desirable quality of endometrium was significantly better in the cycle
when HBO therapy had been applied (p< 0.001). The doppler flowmetry of the
uterine arteries indicated that the uterine blood vessel resistance was slightly
higher than expected. Mapping of subendometrial blood vessels in the cycles
covered by hyperbaric oxygen therapy showed the intensive capillary network of
endometrium with low resistance Ri< 0.45. The oxygen used under higher pressure
-- oxygen as a drug , may have an extraordinary significance for better outcome
of pregnancy implantation by improving endometrial receptivity. If endometrial
receptivity is conditioned by adequate vascularisation and oxygenation, then
hyperbaric oxygen therapy is the treatment of choice.
DOI: 10.17305/bjbms.2006.3168
PMID: 16879108 [Indexed for MEDLINE]
