Author(s) Weaver LK, Churchill S, et al.

Journal Chest. Date of publication 2001 Oct 1;volume 120(4):1407-9.

Abstract 1. Chest. 2001 Oct;120(4):1407-9. Pulmonary edema associated with hyperbaric oxygen therapy. Weaver LK(1), Churchill S. Author information: (1)Department of Hyperbaric Medicine, LDS Hospital, Salt Lake City, UT 84143, USA. lweaver@ihc.com We report three cases of pulmonary edema associated with hyperbaric oxygen therapy, including one fatality. All three patients had cardiac disease and reduced left ventricular (LV) ejection fractions (EFs). Two patients had diabetes, and one patient had severe aortic stenosis. Hyperbaric oxygen therapy may contribute to pulmonary edema by increasing LV afterload, increasing LV filling pressures, increasing oxidative myocardial stress, decreasing LV compliance by oxygen radical-mediated reduction in nitric oxide, altering cardiac output between the right and left hearts, inducing bradycardia with concomitant LV dysfunction, increasing pulmonary capillary permeability, or by causing pulmonary oxygen toxicity. We advise caution in the use of hyperbaric oxygen therapy in patients with heart failure or in patients with reduced cardiac EFs. DOI: 10.1378/chest.120.4.1407 PMID: 11591590 [Indexed for MEDLINE]

Source ID (e.g. PMID): 11591590