Abel FL, McNamee JE, Cone DL, Clarke D, Tao J, et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, In.... Date of publication 2000 Jul 1;volume 27(2):67-73.
1. Undersea Hyperb Med. 2000 Summer;27(2):67-73.
Effects of hyperbaric oxygen on ventricular performance, pulmonary blood volume,
and systemic and pulmonary vascular resistance.
Abel FL(1), McNamee JE, Cone DL, Clarke D, Tao J.
Author information:
(1)Department of Pharmacology, Family Medicine, University of South Carolina
School of Medicine, Columbia 29208, USA.
Comment in
Undersea Hyperb Med. 2000 Winter;27(4):215-6.
The cardiovascular effects of hyperbaric (3 atm abs) air, 100% oxygen, and
hyperbaric oxygen (HBO2) at 3 atm abs were investigated in 13
pentobarbital-anesthetized dogs. We measured heart rate, arterial pressure,
pulmonary artery pressure, right atrial pressure, left and right ventricular
pressure, and cardiac output. From these we determined end diastolic pressure,
+/-maximal dp/dt, maximal (dp/p), end systolic elastance, cardiac work, and
systemic (SVR) and pulmonary vascular resistance (PVR). Pulmonary blood volume
was obtained from the mean transit time of ascorbic acid. The significant results
with HBO2 were a decrease in heart rate, cardiac output, and cardiac work. All
left ventricular performance indices decreased, without a change in preload or
afterload. In contrast, only right ventricular -dp/dt decreased. SVR increased
but PVR did not change; 100% O2 produced similar but less pronounced responses.
Hyperbaric air had only mild effects. Pulmonary blood volume and lung wet/dry
ratio did not change. Our data suggest that HBO2 may act by a differential effect
on the autonomic innervation of the right and left ventricles. The resultant
ventricular imbalance may be of clinical importance in the mechanism of pulmonary
edema in patients in congestive heart failure undergoing hyperbaric therapy.
PMID: 11011796 [Indexed for MEDLINE]
