Carvalho MR, Silveira IA, Oliveira BGRB, et al.
Revista brasileira de enfermagem. Date of publication 2019 Jan 1;volume 72(1):200-210.
1. Rev Bras Enferm. 2019 Jan-Feb;72(1):200-210. doi: 10.1590/0034-7167-2017-0865.
Treatment of venous ulcers with growth factors: systematic review and
meta-analysis.
[Article in English, Portuguese]
Carvalho MR(1), Silveira IA(1), Oliveira BGRB(1).
Author information:
(1)Universidade Federal Fluminense, Escola de Enfermagem Aurora de Afonso Costa.
Niterói, Rio de Janeiro, Brazil.
OBJECTIVE: To identify evidence about the effects of growth factor application on
venous ulcer healing.
METHOD: Systematic review and meta-analysis, including Randomized Clinical
Trials. Searches: Ovid MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL, LILACS, Web of
Science, Digital Library of Theses and Dissertations; Google Scholar and list of
references.
RESULTS: 802 participants were recruited from the 10 included studies: 472 in the
intervention group (growth factors) and 330 as control. The relative risk for the
complete healing outcome was 1.06 [95% CI 0.92-1.22], p = 0.41. Participants who
received Platelet-Rich Plasma and Epidermal Growth Factor showed a slight
tendency to achieve complete healing, but without statistical relevance (p
<0.05). Most of the studies were classified as moderate risk of bias.
CONCLUSION: The effect of the application of growth factors for complete healing
in venous ulcers is not clear, and clinical trials with methodological quality
are required for more accurate recommendations.
DOI: 10.1590/0034-7167-2017-0865
PMID: 30916287 [Indexed for MEDLINE]
