Rodgers K, Jadhav SS, et al.
Advanced drug delivery reviews. Date of publication 2018 Jan 1;volume 123():75-81.
1. Adv Drug Deliv Rev. 2018 Jan 1;123:75-81. doi: 10.1016/j.addr.2017.10.003. Epub
2017 Oct 12.
The application of mesenchymal stem cells to treat thermal and radiation burns.
Rodgers K(1), Jadhav SS(2).
Author information:
(1)Center for Innovation in Brain Sciences, College of Medicine, Department of
Pharmacology, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ
85724, United States. Electronic address: krodgers@email.arizona.edu.
(2)Beckman Research Centre, Department of Experimental Therapeutics, City of
Hope, Duarte, CA 91010, United States. Electronic address: sajadhav@coh.org.
Mesenchymal stem cells (MSCs) have been developed for a number of indications due
to their regenerative and anti-inflammatory phenotypes and their utility is
enhanced by the fact that allogeneic transplant is feasible with this cell type.
Animal studies and early human cases indicate that this has the potential to be
an exciting new therapy for treating chronic non-healing wounds such as diabetic
ulcers, burns and cutaneous radiation burns. This review will focus on the use of
MSCs to treat thermal and radiation burns. Large, severe burns are difficult to
treat and pose a major public health burden worldwide. They are characterized by
an extensive loss of the outer protective barrier, delayed wound healing,
increased oxidative stress and a heightened inflammatory state. The breakdown of
the protective barrier results in increased susceptibility to fluid loss and
bacterial sepsis. In the case of radiation burns, chronic inflammation can result
in subsequent waves of tissue injury leading to skin breakdown and necrosis. The
aim of this review is to summarize the current knowledge on MSCs in treating
thermal and radiation burns along with the specific scope of characterizing the
biologic function of MSCs that help enhance wound healing in these chronic
injuries.
Copyright © 2017. Published by Elsevier B.V.
DOI: 10.1016/j.addr.2017.10.003
PMID: 29031640
