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Rodgers K, Jadhav SS, et al.
Advanced drug delivery reviews. Date of publication 2018 Jan 1;volume 123():75-81.
1. Adv Drug Deliv Rev. 2018 Jan 1;123:75-81. doi: 10.1016/j.addr.2017.10.003. Epub 2017 Oct 12. The application of mesenchymal stem cells to treat thermal and radiation burns. Rodgers K(1), Jadhav SS(2). Author information: (1)Center for Innovation in Brain Sciences, College of Medicine, Department of Pharmacology, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724, United States. Electronic address: krodgers@email.arizona.edu. (2)Beckman Research Centre, Department of Experimental Therapeutics, City of Hope, Duarte, CA 91010, United States. Electronic address: sajadhav@coh.org. Mesenchymal stem cells (MSCs) have been developed for a number of indications due to their regenerative and anti-inflammatory phenotypes and their utility is enhanced by the fact that allogeneic transplant is feasible with this cell type. Animal studies and early human cases indicate that this has the potential to be an exciting new therapy for treating chronic non-healing wounds such as diabetic ulcers, burns and cutaneous radiation burns. This review will focus on the use of MSCs to treat thermal and radiation burns. Large, severe burns are difficult to treat and pose a major public health burden worldwide. They are characterized by an extensive loss of the outer protective barrier, delayed wound healing, increased oxidative stress and a heightened inflammatory state. The breakdown of the protective barrier results in increased susceptibility to fluid loss and bacterial sepsis. In the case of radiation burns, chronic inflammation can result in subsequent waves of tissue injury leading to skin breakdown and necrosis. The aim of this review is to summarize the current knowledge on MSCs in treating thermal and radiation burns along with the specific scope of characterizing the biologic function of MSCs that help enhance wound healing in these chronic injuries. Copyright © 2017. Published by Elsevier B.V. DOI: 10.1016/j.addr.2017.10.003 PMID: 29031640
Appears in following Topics:
Acute Burns - Treatment