Maranda EL, Rodriguez-Menocal L, Badiavas EV, et al.
Current stem cell research & therapy. Date of publication 2017 Jan 1;volume 12(1):61-70.
1. Curr Stem Cell Res Ther. 2017;12(1):61-70.
Role of Mesenchymal Stem Cells in Dermal Repair in Burns and Diabetic Wounds.
Maranda EL, Rodriguez-Menocal L, Badiavas EV(1).
Author information:
(1)University of Miami, Interdisciplinary Stem Cell Institute, 1501 NW 10th
Street, Suite 924, Miami, FL 33136, USA.
In this review we explore stem cell function in wounds that are resistant to
healing, such as burn injuries and diabetic wounds. Diabetic ulcers are of
interest due to their remarkable resistance to heal; severe thermal burns are
addressed due to critical need for effective therapies for the prevention shock
and improvement in scarring. Cell-based therapy utilizing mesenchymal stem cells
(MSCs), also known as mesenchymal stromal cells, are currently being investigated
as a therapeutic avenue for both chronic diabetic ulcers and severe thermal
burns. The clinical utility of stem cells, in particular MSCs, in caring for
these types of injuries is primarily based on repairing and replacing cellular
substrates, attenuation of inflammation, increasing angiogenesis, and enhancing
migration of reparative cells. MSCs are sought after due to their unique ability
to initiate different wound-healing programs, depending on the environmental
milieu. Thus, this review aims to highlight the properties of MSCs, including
their characterization, immunogenicity, and function in the context of dermal
repair and regeneration in severe burns and diabetic wounds. Additionally,
relevant clinical and pre-clinical studies illustrating the impact of allogeneic
and autologous sources of MSCs on therapeutic efficacy are reviewed. Insight into
the properties of MSCs and the dramatic host-to-MSC interactions within these
pathological states may lead to the development of effective strategies for
improving outcomes in impaired wounds.
PMID: 27412677 [Indexed for MEDLINE]
