Hatibie MJ, Islam AA, Hatta M, Moenadjat Y, Susilo RH, Rendy L, et al.
Advances in skin & wound care. Date of publication 2019 Mar 1;volume 32(3):1-4.
1. Adv Skin Wound Care. 2019 Mar;32(3):1-4. doi: 10.1097/01.ASW.0000553110.78375.7b.
Hyperbaric Oxygen Therapy for Second-Degree Burn Healing: An Experimental Study
in Rabbits.
Hatibie MJ(1), Islam AA, Hatta M, Moenadjat Y, Susilo RH, Rendy L.
Author information:
(1)In Indonesia, Mendy J. Hatibie, MD, is Head of the Division of Plastic
Surgery, University of Sam Ratulangi, Faculty of Medicine, Manado; Andi A. Islam,
MD, PhD, is Dean and Professor, Department of Surgery, University of Hasanuddin,
Faculty of Medicine, Makassar; Mochammad Hatta, MD, PhD, is Head of the Molecular
Biology and Immunology Laboratory, University of Hasanuddin, Faculty of Medicine,
Makassar; Yefta Moenadjat, MD, PhD is a Lecturer, Department of Surgery,
University of Indonesia, Faculty of Medicine, Jakarta; Rudy H. Susilo, MD, is a
general surgeon, Department of Surgery, University of Sam Ratulangi, Faculty of
Medicine, Manado; and Leo Rendy, MD, is a general surgeon, Department of Surgery,
University of Sam Ratulangi, Faculty of Medicine, Manado. The authors have
disclosed no financial relationships related to this article. Submitted August
25, 2018; accepted in revised form October 9, 2018.
BACKGROUND: The wound healing process includes inflammation, proliferation, and
remodelling phases, the main features of which are inflammation, neoangiogenesis,
and epithelialization. Hyperbaric oxygen therapy (HBOT) is one modality
postulated to improve wound healing. The objective of this study was to determine
whether HBOT could improve selected features of burn wound healing in an
experimental rabbit model.
METHODS: Researchers conducted an experimental study with 36 rabbits given
second-degree burns. Subjects were separated into two groups: a control group (n
= 18) and an intervention group that was given HBOT at 2.4 atmospheres absolute
for 6 days (n = 18). The main outcome measure was wound healing.
RESULTS: Compared with the control group, the HBOT group showed more robust
inflammatory cells (P = .025) and epithelialization (P = .024), but no
significant difference in angiogenesis (P = .442).
CONCLUSIONS: The authors conclude that HBOT may improve second-degree burn
healing by increasing inflammatory cell migration and re-epithelialization.
DOI: 10.1097/01.ASW.0000553110.78375.7b
PMID: 30801355
