Dillingham CS, Jorizzo J, et al.
Advances in skin & wound care. Date of publication 2019 Feb 1;volume 32(2):70-76.
1. Adv Skin Wound Care. 2019 Feb;32(2):70-76. doi:
10.1097/01.ASW.0000546120.32681.bc.
Managing Ulcers Associated with Pyoderma Gangrenosum with a Urinary Bladder
Matrix and Negative-Pressure Wound Therapy.
Dillingham CS(1), Jorizzo J.
Author information:
(1)At the Wake Forest Baptist Medical University in Winston-Salem, North
Carolina, Claire Sanger Dillingham, DO, is Associate Professor, Plastic and
Reconstructive Surgery Department; and Joseph Jorizzo, MD, is Professor,
Dermatology Department. The authors have disclosed no financial relationships
related to this article. Submitted March 21, 2018; accepted in revised form June
12, 2018.
Pyoderma gangrenosum (PG) is a rare disease that presents as painful ulcerations
with inflammation and undermining at the borders. The ulcers can occur anywhere
on the body but are most commonly seen on the lower extremities. The etiology of
PG is unknown, and there are no definitive diagnostic criteria; PG is a diagnosis
of exclusion, which can present serious delays in treatment.Patients should be
treated with an interdisciplinary approach with aggressive immunosuppression,
treatment of any comorbidities, maximization of nutrition status, reconstructive
surgery for treatment of the wound, and physical therapy for deconditioning.This
article presents a case study of one patient treated with a porcine urinary
bladder matrix and negative-pressure wound therapy; this treatment combination
provided pain relief, coverage of the wound, an acceptable aesthetic outcome, and
long-term stability.
DOI: 10.1097/01.ASW.0000546120.32681.bc
PMID: 30653185
