WoundReference improves clinical decisions
 Choose the role that best describes you
Borda LJ, Wong LL, Marzano AV, Ortega-Loayza AG, et al.
Archives of dermatological research. Date of publication 2019 Mar 29;volume ():.
1. Arch Dermatol Res. 2019 Mar 29. doi: 10.1007/s00403-019-01912-1. [Epub ahead of print] Extracutaneous involvement of pyoderma gangrenosum. Borda LJ(1), Wong LL(1), Marzano AV(2), Ortega-Loayza AG(3). Author information: (1)Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA. (2)UOC Dermatologia, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy. (3)Department of Dermatology and OHSU Wound and Hyperbaric Medicine, Oregon Health and Science University, 3303 SW Bond Ave Center for Health and Healing Building 1, Suite 16, Portland, OR, 97239, USA. ortegalo@ohsu.edu. Pyoderma Gangrenosum (PG) is an inflammatory neutrophilic dermatosis (ND) associated with underlying chronic inflammation and/or malignancy. Diagnosis remains to be challenging as a gold standard diagnostic test is lacking. Initial manifestations may include papules, vesicles, or pustules that subsequently develop into ulceration with features of undermining and violaceous borders. Timely recognition of pyoderma gangrenosum is impeded by clinical findings shared with other etiologies, such as granulomatosis with polyangiitis, polyarteritis nodosa, and antiphospholipid syndrome. As with any other ND, extracutaneous involvement may also occur preceding, during, or following the appearance of skin lesions. Sterile neutrophilic infiltrates have been found to affect internal organs supporting the concept of PG being a systemic disease, with lung being the most common extracutaneous manifestation followed by ocular and visceral compromise. Therefore, in this review, we describe the current knowledge of extracutaneous involvement of PG and its respective clinical manifestations to aid dermatologists in diagnosis, management, and determining prognosis. DOI: 10.1007/s00403-019-01912-1 PMID: 30923901
Appears in following Topics:
Pyoderma Gangrenosum - Introduction and Assessment