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Jenwitheesuk K, Mahakkanukrauh A, Punjaruk W, Jenwitheesuk K, Chowchuen B, Jinaporntham S, Uraiwan K, Limrattanapimpa P, et al.
BioResearch open access. Date of publication 2018 Oct 8;volume 7(1):145-149.
1. Biores Open Access. 2018 Oct 8;7(1):145-149. doi: 10.1089/biores.2018.0019. eCollection 2018. Efficacy of Adjunctive Hyperbaric Oxygen Therapy in Osteoradionecrosis. Jenwitheesuk K(1), Mahakkanukrauh A(2), Punjaruk W(3), Jenwitheesuk K(4)(5), Chowchuen B(1), Jinaporntham S(6), Uraiwan K(7), Limrattanapimpa P(8). Author information: (1)Plastic and Reconstructive Surgery Unit, Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. (2)Division of Allergy-Immunology-Rheumatology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. (3)Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. (4)General Surgery Unit, Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. (5)Sleep Apnea Research Group, Research Center in Back, Neck and Other Joint Pain and Human Performance, Khon Kaen University, Khon Kaen, Thailand. (6)Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand. (7)Department of Dental, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. (8)Hospital Hyperbaric Oxygen Therapy Unit, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. Osteoradionecrosis (ORN) is a common consequence resulting from radiation in patients with cancer. Presently, hyperbaric oxygen therapy (HBOT) is proposed to have a role in improving wound healing in ORN patients. There is no strong scientific evidence to confirm the benefits of HBOT for treatment of ORN as an adjunctive treatment. This study aimed to determine the benefits of adjunctive treatment of HBOT in ORN. A retrospective study was conducted at the Srinagarind Hospital, the Faculty of Medicine, Khon Kaen University, Thailand, between 2011 and 2017. The patients diagnosed with ORN, who received adjunctive HBOT before the operation, were enrolled. Complete healing of wounds was the primary outcome. There were 84 ORN patients with a mean age of 58.78 years; 54.76% were male and 45.24% were female. HBOT had a role significant in improving wound healing of ORN patients with stages 1 and 2. Poisson regression analysis showed that stage 3 of ORN negatively correlated with the number of HBOT dives (p = 0.001, incidence rates ratio = 0.85). In conclusion, HBOT improved wound healing of ORN patients with stages 1 and 2. In addition, stage 2 of ORN patients significantly required the highest number of HBOT dives compared to other types of ORN to promote wound healing, whereas stage 3 patients, who underwent bone debridement combined with HBOT, initiated to success of treatment process and required a smaller number of dives. DOI: 10.1089/biores.2018.0019 PMCID: PMC6178923 PMID: 30310729 Conflict of interest statement: No competing financial interests exist.
Appears in following Topics:
Osteoradionecrosis - Mandibular