Wang Y, Gao Y, Wang B, Chen L, Zhang X, et al.
American journal of audiology. Date of publication 2019 Mar 15;volume 28(1):95-100.
1. Am J Audiol. 2019 Mar 15;28(1):95-100. doi: 10.1044/2018_AJA-18-0095.
Efficacy and Prognostic Factors of Combined Hyperbaric Oxygen Therapy in Patients
With Idiopathic Sudden Sensorineural Hearing Loss.
Wang Y(1), Gao Y(1), Wang B(2), Chen L(2), Zhang X(1).
Author information:
(1)Rehabilitation Medicine Center, Fuxing Hospital, Capital Medical University,
Beijing, China.
(2)Department of Otolaryngology Head and Neck Surgery, Fuxing Hospital, Capital
Medical University, Beijing, China.
Purpose Idiopathic sudden sensorineural hearing loss is a clinical emergency with
an increased incidence of occurrence in recent years. Hyperbaric oxygen has been
widely used in the clinical treatment of sudden hearing loss. However, prognostic
factors related to its curative effects are still not clear, which hinders its
clinical application. The aim of this study was to investigate the efficacy and
prognostic factors of hyperbaric oxygen therapy (HBOT) plus drug therapies in the
treatment of sudden hearing loss. Method Patients with sudden hearing loss who
were treated with hyperbaric oxygen from April to October 2017 were
retrospectively included. Clinical information was collected, including pure-tone
audiometry data before and after hyperbaric oxygen treatment, age, gender,
hearing curve classification, concomitant symptoms, history of diseases (diabetes
and hypertension), history of hormone therapy, start time of hyperbaric oxygen
treatment, and total number of hyperbaric oxygen treatments. The prognostic
factors were analyzed with univariate and multivariate analyses. Results
Sixty-four patients with sudden hearing loss were enrolled, including 7 cases of
low-frequency loss, 4 cases of high-frequency loss, 32 cases of flat loss, and 21
cases of complete hearing loss. After HBOT, there were 16 cases (25%) of complete
recovery, 15 cases (23.43%) of partial recovery, 7 cases (10.93%) of slight
improvement, and 26 cases (40.63%) of no improvement. The total effective rate
was 59.37%. Twelve of 21 cases (57.14%) of complete hearing loss showed recovery.
Multivariate logistic regression analysis showed that the start time of HBOT ≤ 7
days from disease onset was independently associated with hearing recovery ( OR =
27.763, 95% CI [4.209, 183.115], p = .001). Conclusion Combined HBOT can improve
the hearing impairment of sudden hearing loss. The early HBOT showed the most
promising therapeutic effects, especially among patients with complete hearing
loss.
DOI: 10.1044/2018_AJA-18-0095
PMID: 30938564
