WoundReference improves clinical decisions
 Choose the role that best describes you
Nabeya R, Kobayashi M, Fujita M, Yorifuji K, Eguchi N, Okamoto S, et al.
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology. Date of publication 1990 Sep 1;volume 100(10):1029-39.
1. Nihon Hifuka Gakkai Zasshi. 1990 Sep;100(10):1029-39. [A case of Stewart-Treves syndrome--treatment with recombinant interleukin 2 and a review of Japanese literature]. [Article in Japanese] Nabeya R(1), Kobayashi M, Fujita M, Yorifuji K, Eguchi N, Okamoto S. Author information: (1)Department of Dermatology, Chiba University School of Medicine. A 76-year-old woman developed angiosarcoma 11 years after a radical mastectomy in the chronic lymphedema of the ipsilateral arm, referred to as Stewart-Treves syndrome. The patient was treated by intravenous and intralesional injection of recombinant interleukin 2 (rIL-2; TGP-3, Takeda Chemical Industries, LTD, Osaka). Intralesional injection was more effective than systemic administration. After a month, the lesion where the local injection was done showed little tumor cells with a dense infiltrate composed of lymphoid cells. It was observed that NK activity, LAK activity and IL-2 receptor positive T-cells in the peripheral blood increased during the administration of rIL-2. As the lesion was too large to be treated with rIL-2 alone, radiotherapy was performed. But the patient had no remarkably improvement and died 16 months later from the onset. Immunotherapy with rIL-2 can be useful for angiosarcoma and more effective regimen of rIL-2 is a important problem. PMID: 2266596 [Indexed for MEDLINE]
Appears in following Topics:
Lymphedema - Treatment and Emerging Strategies for Prevention