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Girgis B, Duarte JA, et al.
Journal of tissue viability. Date of publication 2018 Nov 1;volume 27(4):274-284.
1. J Tissue Viability. 2018 Nov;27(4):274-284. doi: 10.1016/j.jtv.2018.08.003. Epub 2018 Aug 11. High Voltage Monophasic Pulsed Current (HVMPC) for stage II-IV pressure ulcer healing. A systematic review and meta-analysis. Girgis B(1), Duarte JA(2). Author information: (1)CIAFEL, Faculty of Sports, University of Porto, Portugal. Electronic address: begirgis@gmail.com. (2)CIAFEL, Faculty of Sports, University of Porto, Portugal. Electronic address: jarduarte@fade.up.pt. This review was conducted to determine and quantify the efficacy of high-voltage monophasic pulsed current (HVMPC) in the treatment of stage II-IV pressure ulcers (PrUs), identify the details of HVMPC intervention parameters and the superior protocol, and ascertain other potential benefits and the safety of HVMPC intervention. Eleven studies, nine randomized controlled trials (RCTs) and two case series studies, matched the criteria and were included in the systematic review, whereas, only level 1 evidence RCTs were included in the meta-analysis. The percentage of wound surface area reduction per week was 12.39%; 95% CI, [10.43-14.37] for HVMPC plus standard wound care (SWC) and 6.96%; 95% CI, [5.56-8.38] for SWC alone or SWC plus sham HVMPC. The net effect of HVMPC was 5.4% per week (an increase of 78% greater than SWC alone or SWC plus sham HVMPC). Level 1, 2 and 4 evidence studies have consistently indicated that HVMPC plus SWC were more effective than SWC alone or SWC plus sham HVMPC in treating stage II-IV PrUs. Level 1 evidence studies showed that HVMPC intervention improved the healing of PrUs (reduced wound surface area), and combined with SWC, increased the probability of complete healing and almost eliminated the probability of worsening of healing. HVMPC intervention was shown to be relatively safe, with rare adverse reactions. Copyright © 2018 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved. DOI: 10.1016/j.jtv.2018.08.003 PMID: 30177421
Appears in following Topics:
Cellular and/or Tissue Based Products
Pressure Ulcers/Injuries - Treatment
Pressure Ulcers/Injuries - Treatment