Ramos-Torrecillas J, García-Martínez O, De Luna-Bertos E, Ocaña-Peinado FM, Ruiz C, et al.
Biological research for nursing. Date of publication 2015 Mar 1;volume 17(2):152-8.
1. Biol Res Nurs. 2015 Mar;17(2):152-8. doi: 10.1177/1099800414535840. Epub 2014 May
20.
Effectiveness of platelet-rich plasma and hyaluronic acid for the treatment and
care of pressure ulcers.
Ramos-Torrecillas J(1), García-Martínez O(1), De Luna-Bertos E(1), Ocaña-Peinado
FM(2), Ruiz C(3).
Author information:
(1)Department of Nursing, Faculty of Health Sciences, University of Granada,
Granada, Spain Instituto Investigación Biosanitaria, Granada, Spain.
(2)Department of Statistics and Operations Research, School of Pharmacy,
University of Granada, Granada, Spain.
(3)Department of Nursing, Faculty of Health Sciences, University of Granada,
Granada, Spain Instituto Investigación Biosanitaria, Granada, Spain Institute of
Neuroscience, University of Granada, Granada, Spain crr@ugr.es.
Platelet-rich growth factor (PRGF) is a natural source of growth factors (GF),
while hyaluronic acid (HA) is a biopolymer present in the extracellular matrix of
skin, cartilage, bone, and brain, among other tissues. Both are involved in the
pathophysiological mechanisms underlying wound healing. The objective of this
study was to evaluate the clinical efficacy (as measured by ulcer area) and
safety (as measured by signs of infection) of PRGF and PRGF plus HA in the
treatment of pressure ulcers (PUs). Patients (N = 100) with 124 Stage II-III PUs
were randomized to a control group (n = 25 PUs) for standard care or to case
groups for treatment with one (n = 34 PUs) or two (n = 25 PUs) doses of PRGF from
their own peripheral blood, or two doses of PRGF plus HA (n = 40 PUs). All ulcers
were followed up every 3 days for a 36-day period. At 36 days, a significant
reduction in ulcer area (p ≤ .001) was observed in all treatment groups, with a
mean reduction of more than 48.0% versus baseline. The greatest mean reduction
(80.4% vs. baseline) was obtained with the PRGF plus HA regimen. Complete wound
healing was observed in 32.0% of PUs treated with two doses of PRGF (p ≤ .002)
and in 37.5% of those treated with two doses of PRGF plus HA (p ≤ .004). There
were no signs of infection in any PUs during the 36-day follow-up period. The
degree of wound healing was inversely correlated with the consumption of drugs
such as statins and with the peripheral blood platelet levels of patients at
baseline.
© The Author(s) 2014.
DOI: 10.1177/1099800414535840
PMID: 24848975 [Indexed for MEDLINE]
