Brown-Etris M, Milne CT, Hodde JP, et al.
Journal of tissue viability. Date of publication 2018 Nov 27;volume ():.
1. J Tissue Viability. 2018 Nov 27. pii: S0965-206X(18)30113-X. doi:
10.1016/j.jtv.2018.11.001. [Epub ahead of print]
An extracellular matrix graft (Oasis® wound matrix) for treating full-thickness
pressure ulcers: A randomized clinical trial.
Brown-Etris M(1), Milne CT(2), Hodde JP(3).
Author information:
(1)Etris Associates, Inc, 14450 Bustleton Avenue, Philadephia, PA, 19116, USA.
Electronic address: mbeetris@aol.com.
(2)Connecticut Clinical Nursing Associates, LLC, 204 Keegan Rd, Plymouth, CT,
06782, USA. Electronic address: ccna2@juno.com.
(3)Cook Biotech Incorporated, 1425 Innovation Place, West Lafayette, IN, 47906,
USA. Electronic address: Jason.Hodde@cookbiotech.com.
AIM: The purpose of the study was to evaluate clinical safety and effectiveness
of Oasis® Wound Matrix as a treatment for full-thickness pressure ulcers and
compare it to Standard Care.
METHODS: A total of 130 adults with Stage III or Stage IV pressure ulcers were
randomly assigned, received either multiple topical treatments of SIS plus
standard care (n = 67), or standard care alone (n = 63), and were subsequently
evaluated. Ulcer size was determined at enrollment and weekly throughout
treatment. Healing was assessed at each visit for a period of up to 12 weeks,
with incidence of complete healing and 90% reduction in ulcer area being the
primary outcome measures.
RESULTS: The proportion of complete healing in the SIS group was 40% as compared
to 29% in the standard of care group (p = 0.111); the percentage of patients
having a 90% reduction in ulcer surface area was 55% in the SIS group versus 38%
in the standard of care group (p = 0.037).
CONCLUSIONS: The results of this study suggest that within the setting of a
comprehensive wound care program, weekly treatment of chronic pressure ulcers
with SIS wound matrix increases the incidence of 90% reduction in wound size
versus standard of care alone.
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.jtv.2018.11.001
PMID: 30509850
