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Brown-Etris M, Milne CT, Hodde JP, et al.
Journal of tissue viability. Date of publication 2018 Nov 27;volume ():.
1. J Tissue Viability. 2018 Nov 27. pii: S0965-206X(18)30113-X. doi: 10.1016/j.jtv.2018.11.001. [Epub ahead of print] An extracellular matrix graft (Oasis® wound matrix) for treating full-thickness pressure ulcers: A randomized clinical trial. Brown-Etris M(1), Milne CT(2), Hodde JP(3). Author information: (1)Etris Associates, Inc, 14450 Bustleton Avenue, Philadephia, PA, 19116, USA. Electronic address: mbeetris@aol.com. (2)Connecticut Clinical Nursing Associates, LLC, 204 Keegan Rd, Plymouth, CT, 06782, USA. Electronic address: ccna2@juno.com. (3)Cook Biotech Incorporated, 1425 Innovation Place, West Lafayette, IN, 47906, USA. Electronic address: Jason.Hodde@cookbiotech.com. AIM: The purpose of the study was to evaluate clinical safety and effectiveness of Oasis® Wound Matrix as a treatment for full-thickness pressure ulcers and compare it to Standard Care. METHODS: A total of 130 adults with Stage III or Stage IV pressure ulcers were randomly assigned, received either multiple topical treatments of SIS plus standard care (n = 67), or standard care alone (n = 63), and were subsequently evaluated. Ulcer size was determined at enrollment and weekly throughout treatment. Healing was assessed at each visit for a period of up to 12 weeks, with incidence of complete healing and 90% reduction in ulcer area being the primary outcome measures. RESULTS: The proportion of complete healing in the SIS group was 40% as compared to 29% in the standard of care group (p = 0.111); the percentage of patients having a 90% reduction in ulcer surface area was 55% in the SIS group versus 38% in the standard of care group (p = 0.037). CONCLUSIONS: The results of this study suggest that within the setting of a comprehensive wound care program, weekly treatment of chronic pressure ulcers with SIS wound matrix increases the incidence of 90% reduction in wound size versus standard of care alone. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved. DOI: 10.1016/j.jtv.2018.11.001 PMID: 30509850
Appears in following Topics:
Cellular and/or Tissue Based Products
Pressure Ulcers/Injuries - Treatment