Juraschek SP, Appel LJ, Anderson CA, Miller ER 3rd, et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation. Date of publication 2013 Apr 1;volume 61(4):547-54.
1. Am J Kidney Dis. 2013 Apr;61(4):547-54. doi: 10.1053/j.ajkd.2012.10.017. Epub
2012 Dec 4.
Effect of a high-protein diet on kidney function in healthy adults: results from
the OmniHeart trial.
Juraschek SP(1), Appel LJ, Anderson CA, Miller ER 3rd.
Author information:
(1)Johns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public
Health, and Welch Center for Prevention, Epidemiology and Clinical Research,
Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
BACKGROUND: Consumption of a diet high in protein can cause glomerular
hyperfiltration, a potentially maladaptive response, which may accelerate the
progression of kidney disease.
STUDY DESIGN: An ancillary study of the OmniHeart trial, a randomized 3-period
crossover feeding trial testing the effects of partial replacement of
carbohydrate with protein on kidney function.
SETTING & PARTICIPANTS: Healthy adults (N=164) with prehypertension or stage 1
hypertension at a community-based research clinic with a metabolic kitchen.
INTERVENTION: Participants were fed each of 3 diets for 6 weeks. Feeding periods
were separated by a 2- to 4-week washout period. Weight was held constant on each
diet. The 3 diets emphasized carbohydrate, protein, or unsaturated fat; dietary
protein was either 15% (carbohydrate and unsaturated fat diets) or 25% (protein
diet) of energy intake.
OUTCOMES: Fasting serum creatinine, cystatin C, and β2-microglobulin levels,
estimated glomerular filtration rate (eGFR).
MEASUREMENTS: Serum creatinine, cystatin C, and β2-microglobulin collected at the
end of each feeding period.
RESULTS: Baseline cystatin C-based eGFR was 92.0±16.3 (SD) mL/min/1.73 m(2).
Compared with the carbohydrate and unsaturated fat diets, the protein diet
increased cystatin C-based eGFR by ~4 mL/min/1.73 m(2) (P < 0.001). The effects
of the protein diet on kidney function were independent of changes in blood
pressure. There was no significant difference between the carbohydrate and
unsaturated fat diets.
LIMITATIONS: Participants did not have kidney disease at baseline.
CONCLUSIONS: A healthy diet rich in protein increased eGFR. Whether long-term
consumption of a high-protein diet leads to kidney disease is uncertain.
Copyright © 2013 National Kidney Foundation, Inc. Published by Elsevier Inc. All
rights reserved.
DOI: 10.1053/j.ajkd.2012.10.017
PMCID: PMC3602135
PMID: 23219108 [Indexed for MEDLINE]
